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Submit ReviewCompetitive NMDA receptor antagonist. Displays Ki values of 0.84, 2.74, 3.53 and 4.16 μM at GluN2A, GluN2B, GluN2C and GluN2D subunit-containing receptors respectively. Selective over AMPA receptors.
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
M. Wt | 224.15 |
Formula | C6H13N2O5P |
Storage | Store at +4°C |
CAS Number | 113919-36-1 |
PubChem ID | 17756792 |
InChI Key | ILRBBHJXTYIHTP-UHFFFAOYSA-N |
Smiles | OP(CN1CC(C(O)=O)NCC1)(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
water | 22.42 | 100 |
The following data is based on the product molecular weight 224.15. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 4.46 mL | 22.31 mL | 44.61 mL |
5 mM | 0.89 mL | 4.46 mL | 8.92 mL |
10 mM | 0.45 mL | 2.23 mL | 4.46 mL |
50 mM | 0.09 mL | 0.45 mL | 0.89 mL |
References are publications that support the biological activity of the product.
Harris and Davies (1992) Cortically evoked excitatory synaptic transmission in the cat red nucleus is antagonised by D-AP5 but not by D-AP7. Brain Res. 594 176 PMID: 1361408
Feng et al (2005) The effect of competitive antagonist chain length on NMDA receptor subunit selectivity. Neuropharmacology 48 354 PMID: 15721167
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Keywords: PMPA (NMDA antagonist), PMPA (NMDA antagonist) supplier, Competitive, NMDA, antagonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, PMPC, 2273, Tocris Bioscience
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PMPA was in use as an NMDA receptor antagonist affecting glutamate site, to study (possible) competition of dopamine for this site. Application of PMPA and dopamine mixtures in different ratios resulted in a decrease of single-channel NMDA receptor openings recorded from outside-out neuron membrane patches. No problem with dissolution in water up to 10 mM concentration.
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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