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Submit ReviewPMPA (NMDA antagonist)
Description: Competitive NMDA antagonist
Alternative Names: PMPC
Chemical Name: 4-(Phosphonomethyl)-2-piperazinecarboxylic acid
Biological Activity
Competitive NMDA receptor antagonist. Displays Ki values of 0.84, 2.74, 3.53 and 4.16 μM at GluN2A, GluN2B, GluN2C and GluN2D subunit-containing receptors respectively. Selective over AMPA receptors.
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
Technical Data
| M. Wt | 224.15 |
| Formula | C6H13N2O5P |
| Storage | Store at +4°C |
| CAS Number | 113919-36-1 |
| PubChem ID | 17756792 |
| InChI Key | ILRBBHJXTYIHTP-UHFFFAOYSA-N |
| Smiles | OP(CN1CC(C(O)=O)NCC1)(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 22.42 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 224.15. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.46 mL | 22.31 mL | 44.61 mL |
| 5 mM | 0.89 mL | 4.46 mL | 8.92 mL |
| 10 mM | 0.45 mL | 2.23 mL | 4.46 mL |
| 50 mM | 0.09 mL | 0.45 mL | 0.89 mL |
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References
References are publications that support the biological activity of the product.
Harris and Davies (1992) Cortically evoked excitatory synaptic transmission in the cat red nucleus is antagonised by D-AP5 but not by D-AP7. Brain Res. 594 176 PMID: 1361408
Feng et al (2005) The effect of competitive antagonist chain length on NMDA receptor subunit selectivity. Neuropharmacology 48 354 PMID: 15721167
If you know of a relevant reference for PMPA (NMDA antagonist), please let us know.
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Keywords: PMPA (NMDA antagonist), PMPA (NMDA antagonist) supplier, Competitive, NMDA, antagonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, PMPC, 2273, Tocris Bioscience
Citations for PMPA (NMDA antagonist)
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Reviews for PMPA (NMDA antagonist)
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Antagonism at NMDA receptor.
By
Sergiy Sylantyev on 11/29/2020
Species: Human
PMPA was in use as an NMDA receptor antagonist affecting glutamate site, to study (possible) competition of dopamine for this site. Application of PMPA and dopamine mixtures in different ratios resulted in a decrease of single-channel NMDA receptor openings recorded from outside-out neuron membrane patches. No problem with dissolution in water up to 10 mM concentration.
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