PLX 647 dihydrochloride

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Cat.No. 5102 - PLX 647 dihydrochloride | C21H17F3N4.2HCl | CAS No. 1779796-38-1
Description: Potent dual Fms/KIT inhibitor
Chemical Name: 5-(1H-Pyrrolo[2,3-b]pyridin-3-ylmethyl)-N-[[4-(trifluoromethyl)phenyl]methyl]-2-pyridinamine dihydrochloride
Purity: ≥97% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent dual KIT/Fms inhibitor (IC50 values are 16 and 28 nM respectively). Inhibits BCR-FMS cell proliferation and osteoclast differentiation in vitro (IC50 values are 92 and 170 nM respectively). Attenuates LPS-induced TNFα and IL-6 release, mast cell activation and macrophage kidney proliferation in vivo.

Compound Libraries

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Technical Data

M. Wt 455.3
Formula C21H17F3N4.2HCl
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 1779796-38-1
PubChem ID 78243730
InChI Key MVMKWLRKACAUTB-UHFFFAOYSA-N
Smiles FC(C(C=C4)=CC=C4CNC(N=C3)=CC=C3CC2=CNC1=NC=CC=C12)(F)F.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.53 100
ethanol 45.53 100

Preparing Stock Solutions

The following data is based on the product molecular weight 455.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.2 mL 10.98 mL 21.96 mL
5 mM 0.44 mL 2.2 mL 4.39 mL
10 mM 0.22 mL 1.1 mL 2.2 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Zhang et al (2013) Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor. Proc.Natl.Acad.Sci.U.S.A. 110 5689 PMID: 23493555


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