PLX 647 dihydrochloride

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Cat.No. 5102 - PLX 647 dihydrochloride | C21H17F3N4.2HCl | CAS No. 1779796-38-1
Description: Potent dual Fms/KIT inhibitor
Chemical Name: 5-(1H-Pyrrolo[2,3-b]pyridin-3-ylmethyl)-N-[[4-(trifluoromethyl)phenyl]methyl]-2-pyridinamine dihydrochloride
Purity: ≥97% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent dual KIT/Fms inhibitor (IC50 values are 16 and 28 nM respectively). Inhibits BCR-FMS cell proliferation and osteoclast differentiation in vitro (IC50 values are 92 and 170 nM respectively). Attenuates LPS-induced TNFα and IL-6 release, mast cell activation and macrophage kidney proliferation in vivo.

Compound Libraries

PLX 647 dihydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 455.3
Formula C21H17F3N4.2HCl
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 1779796-38-1
PubChem ID 78243730
InChI Key MVMKWLRKACAUTB-UHFFFAOYSA-N
Smiles FC(C(C=C4)=CC=C4CNC(N=C3)=CC=C3CC2=CNC1=NC=CC=C12)(F)F.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.53 100
ethanol 45.53 100

Preparing Stock Solutions

The following data is based on the product molecular weight 455.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.2 mL 10.98 mL 21.96 mL
5 mM 0.44 mL 2.2 mL 4.39 mL
10 mM 0.22 mL 1.1 mL 2.2 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Zhang et al (2013) Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor. Proc.Natl.Acad.Sci.U.S.A. 110 5689 PMID: 23493555


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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

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