PIT 1

Pricing Availability Delivery Time Qty
Cat.No. 4168 - PIT 1 | C14H10ClN3O4S | CAS No. 53501-41-0
Description: PIP3 antagonist. Blocks PIP3-PH interaction; inhibits Akt signaling
Chemical Name: N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective PIP3 antagonist. Blocks the binding of PIP3 to the pleckstrin homology (PH) domain of Akt (IC50 = 31.03 μM). Inhibits cancer cell survival and induces apoptosis by inhibition of PIP3-dependent PI 3-kinase/Akt signaling. Exhibits antitumor activity in vivo.

Technical Data

M. Wt 351.76
Formula C14H10ClN3O4S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 53501-41-0
PubChem ID 3664359
InChI Key RIGXBXPAOGDDIG-UHFFFAOYSA-N
Smiles ClC1=C(O)C(NC(NC(C2=CC=CC=C2)=O)=S)=CC([N+]([O-])=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.38 75
ethanol 3.52 10

Preparing Stock Solutions

The following data is based on the product molecular weight 351.76. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.84 mL 14.21 mL 28.43 mL
5 mM 0.57 mL 2.84 mL 5.69 mL
10 mM 0.28 mL 1.42 mL 2.84 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Miao et al (2010) Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains. Proc.Natl.Acad.Sci. 107 2012 PMID:


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Keywords: PIT1 Supplier Akt signaling inhibitors inhibits blocks PH-PIP3 pleckstrin homology PITenins Inositol Lipids

Citations for PIT 1

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for PIT 1

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