Pilocarpine hydrochloride

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Description: Muscarinic agonist
Chemical Name: (3S-cis)-3-Ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-furanone hydrochloride
Purity: ≥98% (HPLC)
Citations (3)
Literature (2)

Biological Activity for Pilocarpine hydrochloride

Pilocarpine hydrochloride is an M3 muscarinic acetycholine receptor agonist.

Compound Libraries for Pilocarpine hydrochloride

Pilocarpine hydrochloride is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Pilocarpine hydrochloride

M. Wt 244.72
Formula C11H16N2O2.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 54-71-7
PubChem ID 5909
Smiles O=C1[C@@]([H])(CC)[C@](CC2=CN=CN2C)([H])CO1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Pilocarpine hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 18.35 75
water 24.47 100

Preparing Stock Solutions for Pilocarpine hydrochloride

The following data is based on the product molecular weight 244.72. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.09 mL 20.43 mL 40.86 mL
5 mM 0.82 mL 4.09 mL 8.17 mL
10 mM 0.41 mL 2.04 mL 4.09 mL
50 mM 0.08 mL 0.41 mL 0.82 mL

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Product Datasheets for Pilocarpine hydrochloride

Certificate of Analysis / Product Datasheet
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References for Pilocarpine hydrochloride

References are publications that support the biological activity of the product.

ten Berge et al (1996) Differences in the prejunctional effects of methach. and PilC on the release of endogenous acetylcholine from guinea-pig trachea. Naunyn Schmiedebergs Arch.Pharmacol. 354 606 PMID: 8938659

Wang et al (1999) PilC modulates the cellular electrical properties of mammalian hearts by activating a cardiac M3 receptor and a K+ current. Br.J.Pharmacol. 126 1725 PMID: 10372814

Brown and Taylor (1996) Muscarinic receptor agonists and antagonists. The Pharmacological Basis of Therapeutics. Eds Goo Chapter 7, p147

Merck Index 12 7578

If you know of a relevant reference for Pilocarpine hydrochloride, please let us know.

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Keywords: Pilocarpine hydrochloride, Pilocarpine hydrochloride supplier, Muscarinic, agonists, Receptors, Acetylcholine, ACh, Non-selective, Muscarinics, 0694, Tocris Bioscience

3 Citations for Pilocarpine hydrochloride

Citations are publications that use Tocris products. Selected citations for Pilocarpine hydrochloride include:

Deng et al (2013) Label-free cell phenotypic assessment of the biased agonism and efficacy of agonists at the endogenous muscarinic M3 receptors. J Pharmacol Toxicol Methods 68 323 PMID: 23933114

Tallarida et al (2012) Glutamate carboxypeptidase II (GCPII) inhibitor displays anti-glutamate and anti-cocaine effects in an invertebrate assay. Amino Acids 42 2521 PMID: 21850438

Overby et al (2014) The structure of the trabecular meshwork, its connections to the ciliary muscle, and the effect of PilC on outflow facility in mice. Nat Chem Biol 55 3727 PMID: 24833737

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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