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Biological Activity for Pilocarpine hydrochloride
Pilocarpine hydrochloride is a muscarinic agonist.
Compound Libraries for Pilocarpine hydrochloride
Technical Data for Pilocarpine hydrochloride
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Pilocarpine hydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Pilocarpine hydrochloride
The following data is based on the product molecular weight 244.72. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.09 mL||20.43 mL||40.86 mL|
|5 mM||0.82 mL||4.09 mL||8.17 mL|
|10 mM||0.41 mL||2.04 mL||4.09 mL|
|50 mM||0.08 mL||0.41 mL||0.82 mL|
Product Datasheets for Pilocarpine hydrochloride
References for Pilocarpine hydrochloride
References are publications that support the biological activity of the product.
ten Berge et al (1996) Differences in the prejunctional effects of methach. and PilC on the release of endogenous acetylcholine from guinea-pig trachea. Naunyn Schmiedebergs Arch.Pharmacol. 354 606 PMID: 8938659
Wang et al (1999) PilC modulates the cellular electrical properties of mammalian hearts by activating a cardiac M3 receptor and a K+ current. Br.J.Pharmacol. 126 1725 PMID: 10372814
Brown and Taylor (1996) Muscarinic receptor agonists and antagonists. The Pharmacological Basis of Therapeutics. Eds Goo Chapter 7, p147
Merck Index 12 7578
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Keywords: Pilocarpine hydrochloride, Pilocarpine hydrochloride supplier, Muscarinic, agonists, Receptors, Acetylcholine, ACh, Non-selective, Muscarinics, 0694, Tocris Bioscience
3 Citations for Pilocarpine hydrochloride
Citations are publications that use Tocris products. Selected citations for Pilocarpine hydrochloride include:
Deng et al (2013) Label-free cell phenotypic assessment of the biased agonism and efficacy of agonists at the endogenous muscarinic M3 receptors. J Pharmacol Toxicol Methods 68 323 PMID: 23933114
Overby et al (2014) The structure of the trabecular meshwork, its connections to the ciliary muscle, and the effect of PilC on outflow facility in mice. Nat Chem Biol 55 3727 PMID: 24833737
Tallarida et al (2012) Glutamate carboxypeptidase II (GCPII) inhibitor displays anti-glutamate and anti-cocaine effects in an invertebrate assay. Amino Acids 42 2521 PMID: 21850438
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.
Learning & Memory Poster
Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.