Pilocarpine hydrochloride

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Cat.No. 0694 - Pilocarpine hydrochloride | C11H16N2O2.HCl | CAS No. 54-71-7
Description: Muscarinic agonist
Chemical Name: (3S-cis)-3-Ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-furanone hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Muscarinic agonist.

Compound Libraries

Pilocarpine hydrochloride is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 244.72
Formula C11H16N2O2.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 54-71-7
PubChem ID 5909
InChI Key RNAICSBVACLLGM-GNAZCLTHSA-N
Smiles O=C1[C@@]([H])(CC)[C@](CC2=CN=CN2C)([H])CO1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 18.35 75
water 24.47 100

Preparing Stock Solutions

The following data is based on the product molecular weight 244.72. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.09 mL 20.43 mL 40.86 mL
5 mM 0.82 mL 4.09 mL 8.17 mL
10 mM 0.41 mL 2.04 mL 4.09 mL
50 mM 0.08 mL 0.41 mL 0.82 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

ten Berge et al (1996) Differences in the prejunctional effects of methacholine and pilocarpine on the release of endogenous acetylcholine from guinea-pig trachea. Naunyn Schmiedebergs Arch.Pharmacol. 354 606 PMID: 8938659

Wang et al (1999) Pilocarpine modulates the cellular electrical properties of mammalian hearts by activating a cardiac M3 receptor and a K+ current. Br.J.Pharmacol. 126 1725 PMID: 10372814

Brown and Taylor (1996) Muscarinic receptor agonists and antagonists. The Pharmacological Basis of Therapeutics. Eds Goo Chapter 7, p147 PMID:

Merck Index 12 7578 PMID:


If you know of a relevant reference for Pilocarpine hydrochloride, please let us know.

View Related Products by Product Action

View all Non-selective Muscarinic Agonists

Keywords: Pilocarpine hydrochloride, supplier, Muscarinic, agonists, Receptors, Acetylcholine, ACh, Non-selective, Muscarinics, Tocris Bioscience

2 Citations for Pilocarpine hydrochloride

Citations are publications that use Tocris products. Selected citations for Pilocarpine hydrochloride include:

Tallarida et al (2012) Glutamate carboxypeptidase II (GCPII) inhibitor displays anti-glutamate and anti-cocaine effects in an invertebrate assay. Amino Acids 42 2521 PMID: 21850438

Overby et al (2014) The structure of the trabecular meshwork, its connections to the ciliary muscle, and the effect of pilocarpine on outflow facility in mice. Nat Chem Biol 55 3727 PMID: 24833737


Do you know of a great paper that uses Pilocarpine hydrochloride from Tocris? If so please let us know.

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