Inhibitor of Na+-glucose cotransporters (SGLT). Produces renal glycosuria and blocks intestinal glucose absorption. Normalizes insulin sensitivity in diabetic rats.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 436.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.29 mL||11.46 mL||22.91 mL|
|5 mM||0.46 mL||2.29 mL||4.58 mL|
|10 mM||0.23 mL||1.15 mL||2.29 mL|
|50 mM||0.05 mL||0.23 mL||0.46 mL|
References are publications that support the biological activity of the product.
Rossetti et al (1987) Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats. J.Clin.Invest. 79 1510 PMID: 3571496
Ehrenkranz et al (2005) Phlorizin: a review. Diabetes Metab Res Rev. 21 31 PMID: 15624123
Wright (2001) Renal Na+-glucose cotransporters. Am.J.Physiol.Renal.Physiol. 280 F10 PMID: 11133510
If you know of a relevant reference for Phlorizin, please let us know.
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Keywords: Phlorizin, Phlorizin supplier, sodium, glucose, cotransporters, SGLT1, SGLT2, glycosuria, hyperglycemia, inhibitors, inhibits, Other, Ion, Pumps/Transporters, 4627, Tocris Bioscience
Citations for Phlorizin
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HL-1 cardiomyocytes were stimulated with Phlorizin (0-200 µM) alone or in combination with LPS (1 µg/ml) for 8 h to follow iNOS expression by Western blot. Phlorizin inhibited LPS-induced iNOS expression starting from 100 µM concentration (shown in Image).
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