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Inhibitor of Na+-glucose cotransporters (SGLT). Produces renal glycosuria and blocks intestinal glucose absorption. Normalizes insulin sensitivity in diabetic rats.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Rossetti et al (1987) Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to Ins in diabetic rats. J.Clin.Invest. 79 1510 PMID: 3571496
Ehrenkranz et al (2005) Phlorizin: a review. Diabetes Metab Res Rev. 21 31 PMID: 15624123
Wright (2001) Renal Na+-glucose cotransporters. Am.J.Physiol.Renal.Physiol. 280 F10 PMID: 11133510
Keywords: Phlorizin, Phlorizin supplier, sodium, glucose, cotransporters, SGLT1, SGLT2, glycosuria, hyperglycemia, inhibitors, inhibits, Other, Ion, Pumps/Transporters, 4627, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for Phlorizin include:
Smith et al (2018) T1R2 receptor-mediated glucose sensing in the upper intestine potentiates glucose absorption through activation of local regulatory pathways. Mol Metab 17 98 PMID: 30201274
Average Rating: 5 (Based on 1 Review.)
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HL-1 cardiomyocytes were stimulated with Phlorizin (0-200 µM) alone or in combination with LPS (1 µg/ml) for 8 h to follow iNOS expression by Western blot. Phlorizin inhibited LPS-induced iNOS expression starting from 100 µM concentration (shown in Image).