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Cat.No. 4627 - Phlorizin | C21H24O10 | CAS No. 60-81-1
Description: Na+-glucose cotransporter (SGLT) inhibitor
Chemical Name: 1-[2-(β-D-Glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone
Purity: ≥99% (HPLC)
Citations (1)
Reviews (1)
Literature (1)

Biological Activity

Inhibitor of Na+-glucose cotransporters (SGLT). Produces renal glycosuria and blocks intestinal glucose absorption. Normalizes insulin sensitivity in diabetic rats.

Technical Data

M. Wt 436.41
Formula C21H24O10
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 60-81-1
PubChem ID 6072
Smiles O=C(CCC2=CC=C(O)C=C2)C1=C(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)C=C(O)C=C1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 43.64 100
ethanol 43.64 100

Preparing Stock Solutions

The following data is based on the product molecular weight 436.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.29 mL 11.46 mL 22.91 mL
5 mM 0.46 mL 2.29 mL 4.58 mL
10 mM 0.23 mL 1.15 mL 2.29 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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References are publications that support the biological activity of the product.

Rossetti et al (1987) Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to Ins in diabetic rats. J.Clin.Invest. 79 1510 PMID: 3571496

Ehrenkranz et al (2005) Phlorizin: a review. Diabetes Metab Res Rev. 21 31 PMID: 15624123

Wright (2001) Renal Na+-glucose cotransporters. Am.J.Physiol.Renal.Physiol. 280 F10 PMID: 11133510

If you know of a relevant reference for Phlorizin, please let us know.

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Keywords: Phlorizin, Phlorizin supplier, sodium, glucose, cotransporters, SGLT1, SGLT2, glycosuria, hyperglycemia, inhibitors, inhibits, Other, Ion, Pumps/Transporters, 4627, Tocris Bioscience

1 Citation for Phlorizin

Citations are publications that use Tocris products. Selected citations for Phlorizin include:

Smith et al (2018) T1R2 receptor-mediated glucose sensing in the upper intestine potentiates glucose absorption through activation of local regulatory pathways. Mol Metab 17 98 PMID: 30201274

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Reviews for Phlorizin

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Phlorizin inhibits LPS-induced iNOS in HL-1 cells.
By Chintan Koyani on 10/22/2018
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: cardiomyocytes

HL-1 cardiomyocytes were stimulated with Phlorizin (0-200 µM) alone or in combination with LPS (1 µg/ml) for 8 h to follow iNOS expression by Western blot. Phlorizin inhibited LPS-induced iNOS expression starting from 100 µM concentration (shown in Image).

review image

Literature in this Area

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