Phlorizin

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Cat.No. 4627 - Phlorizin | C21H24O10 | CAS No. 60-81-1
Description: Na+-glucose cotransporter (SGLT) inhibitor
Chemical Name: 1-[2-(β-D-Glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Inhibitor of Na+-glucose cotransporters (SGLT). Produces renal glycosuria and blocks intestinal glucose absorption. Normalizes insulin sensitivity in diabetic rats.

Technical Data

M. Wt 436.41
Formula C21H24O10
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 60-81-1
PubChem ID 6072
InChI Key IOUVKUPGCMBWBT-QNDFHXLGSA-N
Smiles O=C(CCC2=CC=C(O)C=C2)C1=C(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)C=C(O)C=C1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.64 100
ethanol 43.64 100

Preparing Stock Solutions

The following data is based on the product molecular weight 436.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.29 mL 11.46 mL 22.91 mL
5 mM 0.46 mL 2.29 mL 4.58 mL
10 mM 0.23 mL 1.15 mL 2.29 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Rossetti et al (1987) Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats. J.Clin.Invest. 79 1510 PMID: 3571496

Ehrenkranz et al (2005) Phlorizin: a review. Diabetes Metab Res Rev. 21 31 PMID: 15624123

Wright (2001) Renal Na+-glucose cotransporters. Am.J.Physiol.Renal.Physiol. 280 F10 PMID: 11133510


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Keywords: Phlorizin, supplier, sodium, glucose, cotransporters, SGLT1, SGLT2, glycosuria, hyperglycemia, Other, Ion, Pumps/Transporters, Other, Ion, Pumps/Transporters, Tocris Bioscience

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