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Synthetic analogue of the polyamine amide toxin found in the venom of the Digger Wasp. Blocks cation channels gated by glutamate and acetylcholine in mammalian and invertebrate neurones.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Donevan and Rogawski (1996) Mutiple actions of arylalkylamino arthropod toxins on the NMDA receptor. Neuroscience 70 361 PMID: 8848146
Eldefrawi et al (1988) Structure and synthesis of a potent glutamate receptor antagonist in wasp venom. Proc.Natl.Acad.Sci.U.S.A. 85 4910 PMID: 2838850
Green et al (1996) Polyamine amides are neuroprotective in cerebellar granule cell cultures challenged with excitatory amino acids. Brain Res. 717 135 PMID: 8738263
Keywords: Philanthotoxin 343 trihydrochloride, Philanthotoxin 343 trihydrochloride supplier, Non-selective, Ionotropic, Glutamate, 0283, Tocris Bioscience
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