Philanthotoxin 343 trihydrochloride

Discontinued Product

Unfortunately Philanthotoxin 343 trihydrochloride (Cat. No. 0283) has been withdrawn from sale for commercial reasons.
Cat.No. 0283 - Philanthotoxin 343 trihydrochloride | CAS No. 115976-93-7
Description: Cation channel blocker
Datasheet
Citations
Reviews
Literature

Biological Activity

Synthetic analogue of the polyamine amide toxin found in the venom of the Digger Wasp. Blocks cation channels gated by glutamate and acetylcholine in mammalian and invertebrate neurones.

Technical Data

M. Wt 544.99
Storage Desiccate at +4°C
CAS Number 115976-93-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 544.99. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.83 mL 9.17 mL 18.35 mL
5 mM 0.37 mL 1.83 mL 3.67 mL
10 mM 0.18 mL 0.92 mL 1.83 mL
50 mM 0.04 mL 0.18 mL 0.37 mL

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Product Datasheets

Certificate of Analysis is currently unavailable
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Safety Datasheet

References

References are publications that support the products' biological activity.

Donevan and Rogawski (1996) Mutiple actions of arylalkylamino arthropod toxins on the NMDA receptor. Neuroscience 70 361 PMID: 8848146

Eldefrawi et al (1988) Structure and synthesis of a potent glutamate receptor antagonist in wasp venom. Proc.Natl.Acad.Sci.U.S.A. 85 4910 PMID: 2838850

Green et al (1996) Polyamine amides are neuroprotective in cerebellar granule cell cultures challenged with excitatory amino acids. Brain Res. 717 135 PMID: 8738263

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Keywords: Philanthotoxin 343 trihydrochloride, supplier, Non-selective, Ionotropic, Glutamate, Non-selective, Ionotropic, Glutamate, Tocris Bioscience

Citations for Philanthotoxin 343 trihydrochloride

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Literature in this Area

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