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Philanthotoxin 343 trihydrochloride
Discontinued ProductPhilanthotoxin 343 trihydrochloride (Cat. No. 0283) has been withdrawn from sale for commercial reasons.
Synthetic analogue of the polyamine amide toxin found in the venom of the Digger Wasp. Blocks cation channels gated by glutamate and acetylcholine in mammalian and invertebrate neurones.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Donevan and Rogawski (1996) Mutiple actions of arylalkylamino arthropod toxins on the NMDA receptor. Neuroscience 70 361 PMID: 8848146
Eldefrawi et al (1988) Structure and synthesis of a potent glutamate receptor antagonist in wasp venom. Proc.Natl.Acad.Sci.U.S.A. 85 4910 PMID: 2838850
Green et al (1996) Polyamine amides are neuroprotective in cerebellar granule cell cultures challenged with excitatory amino acids. Brain Res. 717 135 PMID: 8738263
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Keywords: Philanthotoxin 343 trihydrochloride, Philanthotoxin 343 trihydrochloride supplier, Non-selective, Ionotropic, Glutamate, 0283, Tocris Bioscience
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Literature in this Area
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Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.