PF 9184

Discontinued Product

PF 9184 (Cat. No. 5917) has been withdrawn from sale for commercial reasons.
Description: Potent microsomal prostaglandin E synthase 1 (mPGES-1) inhibitor
Chemical Name: N-[3',4'-Dichloro(1,1'-biphenyl)-yl]-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
Purity: ≥98% (HPLC)

Biological Activity for PF 9184

PF 9184 is a potent microsomal prostaglandin E synthase 1 (mPGES-1) inhibitor (IC50 values are 16.5 and 1080 nM for human and rat mPGES-1, respectively). Exhibits >6500-fold selectivity for mPGES-1 over COX-1 and COX-2. Inhibits IL-1β-induced PGE2 synthesis in vitro.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for PF 9184

M. Wt 461.32
Formula C21H14Cl2N2O4S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1221971-47-6
PubChem ID 54728414
Smiles OC2=C(C(NC3=CC=C(C4=CC=C(Cl)C(Cl)=C4)C=C3)=O)NS(C1=CC=CC=C12)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for PF 9184

References are publications that support the biological activity of the product.

Mbalaviele et al (2010) Distinction of microsomal prostaglandin E synthase-1 (mPGES-1) inhibition from cyclooxygenase-2 inhibition in cells using a novel, selective mPGES-1 inhibitor. Biochem.Pharmacol. 79 1445 PMID: 20067770

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Keywords: PF 9184, PF 9184 supplier, PF9184, potent, microsomal, prostaglandins-E, synthases, mPGES-1, inhibitors, inhibits, Other, Synthases/Synthetases, 5917, Tocris Bioscience

Citations for PF 9184

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Currently there are no citations for PF 9184.

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