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PF 9184 is a potent microsomal prostaglandin E synthase 1 (mPGES-1) inhibitor (IC50 values are 16.5 and 1080 nM for human and rat mPGES-1, respectively). Exhibits >6500-fold selectivity for mPGES-1 over COX-1 and COX-2. Inhibits IL-1β-induced PGE2 synthesis in vitro.
Sold for research purposes under agreement from Pfizer Inc.
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The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Mbalaviele et al (2010) Distinction of microsomal prostaglandin E synthase-1 (mPGES-1) inhibition from cyclooxygenase-2 inhibition in cells using a novel, selective mPGES-1 inhibitor. Biochem.Pharmacol. 79 1445 PMID: 20067770
Keywords: PF 9184, PF 9184 supplier, PF9184, potent, microsomal, prostaglandins-E, synthases, mPGES-1, inhibitors, inhibits, Other, Synthases/Synthetases, 5917, Tocris Bioscience
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