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Cat.No. 5549 - Perlapine | C19H21N3 | CAS No. 1977-11-3
Description: Potent and selective hM3Dq DREADD agonist
Chemical Name: 6-(4-Methyl-1-piperazinyl)-11H-dibenz[b,e]azepine
Purity: ≥99% (HPLC)

Biological Activity

Potent and selective hM3Dq DREADD agonist (EC50 = 2.8 nM). Exhibits >10,000-fold selectivity for hM3Dq over hM3.

Technical Data

M. Wt 291.39
Formula C19H21N3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 1977-11-3
PubChem ID 16106
Smiles CN(CC4)CCN4C1=NC(C=CC=C3)=C3CC2=C1C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 14.57 50
ethanol 14.57 50
water 1.46 5mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 291.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.43 mL 17.16 mL 34.32 mL
5 mM 0.69 mL 3.43 mL 6.86 mL
10 mM 0.34 mL 1.72 mL 3.43 mL
50 mM 0.07 mL 0.34 mL 0.69 mL

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References are publications that support the products' biological activity.

Chen et al (2015) The first structure-activity relationship studies for designer receptors exclusively activated by designer drugs. ACS Chem.Neurosci. 6 476 PMID: 25587888

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