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Biological Activity for Pentostatin
Pentostatin is an irreversible inhibitor of adenosine deaminase (Ki = 2.5 pM). Anticancer agent.
Technical Data for Pentostatin
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Pentostatin
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Pentostatin
The following data is based on the product molecular weight 268.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.73 mL||18.64 mL||37.28 mL|
|5 mM||0.75 mL||3.73 mL||7.46 mL|
|10 mM||0.37 mL||1.86 mL||3.73 mL|
|50 mM||0.07 mL||0.37 mL||0.75 mL|
References for Pentostatin
References are publications that support the biological activity of the product.
Klohs and Kraker (1992) Pentostatin: future directions. Pharmacol.Rev. 44 459 PMID: 1480666
Nabhan et al (2004) Purine nucleoside analogues and combination therapies in B-cell chronic lymphocytic leukemia: dawn of a new era. Leukemia Res. 28 429
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Keywords: Pentostatin, Pentostatin supplier, adenosines, deaminases, inhibitors, inhibits, antimetabolites, chemotherapeutics, Deoxycoformycin, Deaminases, 2033, Tocris Bioscience
3 Citations for Pentostatin
Citations are publications that use Tocris products. Selected citations for Pentostatin include:
Ledderose et al (2016) Adenosine arrests breast cancer cell motility by A3 receptor stimulation. Purinergic Signalling PMID: 27577957
Li et al (2015) Inhibition of adenosine deaminase (ADA)-mediated metabolism of cordycepin by natural substances. PLoS Comput Biol 3 e00121 PMID: 26038697
Song (2017) Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent. Nat Commun 8 14108 PMID: 28169986
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.