Irreversible inhibitor of adenosine deaminase (Ki = 2.5 pM). Anticancer agent.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 268.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.73 mL||18.64 mL||37.28 mL|
|5 mM||0.75 mL||3.73 mL||7.46 mL|
|10 mM||0.37 mL||1.86 mL||3.73 mL|
|50 mM||0.07 mL||0.37 mL||0.75 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Klohs and Kraker (1992) Pentostatin: future directions. Pharmacol.Rev. 44 459 PMID: 1480666
If you know of a relevant reference for Pentostatin, please let us know.
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Keywords: adenosines deaminases inhibitors inhibits antimetabolites chemotherapeutics Deoxycoformycin Deaminases
3 Citations for Pentostatin
Citations are publications that use Tocris products. Selected citations for Pentostatin include:
Song (2017) Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent. Nat Commun 8 14108 PMID: 28169986
Ledderose et al (2016) Adenosine arrests breast cancer cell motility by A3 receptor stimulation. Purinergic Signalling PMID: 27577957
Li et al (2015) Inhibition of adenosine deaminase (ADA)-mediated metabolism of cordycepin by natural substances. PLoS Comput Biol 3 e00121 PMID: 26038697
Do you know of a great paper that uses Pentostatin from Tocris? If so please let us know.