Pentostatin

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Cat.No. 2033 - Pentostatin | C11H16N4O4 | CAS No. 53910-25-1
Description: Adenosine deaminase inhibitor
Alternative Names: Deoxycoformycin
Chemical Name: (8R)-3-(2-Deoxy-β-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Literature

Biological Activity

Irreversible inhibitor of adenosine deaminase (Ki = 2.5 pM). Anticancer agent.

Technical Data

M. Wt 268.27
Formula C11H16N4O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 53910-25-1
PubChem ID 439693
InChI Key FPVKHBSQESCIEP-JQCXWYLXSA-N
Smiles O[C@@H]1[C@@H](CO)O[C@@H](N2C(N=CNC[C@H]3O)=C3N=C2)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.12 75
water 26.83 100

Preparing Stock Solutions

The following data is based on the product molecular weight 268.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.73 mL 18.64 mL 37.28 mL
5 mM 0.75 mL 3.73 mL 7.46 mL
10 mM 0.37 mL 1.86 mL 3.73 mL
50 mM 0.07 mL 0.37 mL 0.75 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Klohs and Kraker (1992) Pentostatin: future directions. Pharmacol.Rev. 44 459 PMID: 1480666

Nabhan et al (2004) Purine nucleoside analogues and combination therapies in B-cell chronic lymphocytic leukemia: dawn of a new era. Leukemia Res. 28 429 PMID:


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Keywords: Pentostatin, supplier, adenosines, deaminases, inhibitors, inhibits, antimetabolites, chemotherapeutics, Deoxycoformycin, Deaminases, Deaminases, Tocris Bioscience

3 Citations for Pentostatin

Citations are publications that use Tocris products. Selected citations for Pentostatin include:

Song (2017) Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent. Nat Commun 8 14108 PMID: 28169986

Ledderose et al (2016) Adenosine arrests breast cancer cell motility by A3 receptor stimulation. Purinergic Signalling PMID: 27577957

Li et al (2015) Inhibition of adenosine deaminase (ADA)-mediated metabolism of cordycepin by natural substances. PLoS Comput Biol 3 e00121 PMID: 26038697


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