Pentostatin

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Cat.No. 2033 - Pentostatin | C11H16N4O4 | CAS No. 53910-25-1
Description: Adenosine deaminase inhibitor
Alternative Names: Deoxycoformycin
Chemical Name: (8R)-3-(2-Deoxy-β-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Reviews
Literature (1)

Biological Activity

Irreversible inhibitor of adenosine deaminase (Ki = 2.5 pM). Anticancer agent.

Technical Data

M. Wt 268.27
Formula C11H16N4O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 53910-25-1
PubChem ID 439693
InChI Key FPVKHBSQESCIEP-JQCXWYLXSA-N
Smiles O[C@@H]1[C@@H](CO)O[C@@H](N2C(N=CNC[C@H]3O)=C3N=C2)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 26.83 100
DMSO 20.12 75

Preparing Stock Solutions

The following data is based on the product molecular weight 268.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.73 mL 18.64 mL 37.28 mL
5 mM 0.75 mL 3.73 mL 7.46 mL
10 mM 0.37 mL 1.86 mL 3.73 mL
50 mM 0.07 mL 0.37 mL 0.75 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Klohs and Kraker (1992) Pentostatin: future directions. Pharmacol.Rev. 44 459 PMID: 1480666

Nabhan et al (2004) Purine nucleoside analogues and combination therapies in B-cell chronic lymphocytic leukemia: dawn of a new era. Leukemia Res. 28 429


If you know of a relevant reference for Pentostatin, please let us know.

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Keywords: Pentostatin, Pentostatin supplier, adenosines, deaminases, inhibitors, inhibits, antimetabolites, chemotherapeutics, Deoxycoformycin, Deaminases, 2033, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Pentostatin, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

3 Citations for Pentostatin

Citations are publications that use Tocris products. Selected citations for Pentostatin include:

Ledderose et al (2016) Adenosine arrests breast cancer cell motility by A3 receptor stimulation. Purinergic Signalling PMID: 27577957

Li et al (2015) Inhibition of adenosine deaminase (ADA)-mediated metabolism of cordycepin by natural substances. PLoS Comput Biol 3 e00121 PMID: 26038697

Song (2017) Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent. Nat Commun 8 14108 PMID: 28169986


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

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