PEAQX tetrasodium salt

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Description: Potent and GluN2A-selective NMDA antagonist
Chemical Name: [[[(1S)-1-(4-Bromophenyl)ethyl]amino](1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl] phosphonic acid tetrasodium salt
Purity: ≥98% (HPLC)
Citations (2)
Literature (6)

Biological Activity for PEAQX tetrasodium salt

PEAQX tetrasodium salt is a potent NMDA receptor antagonist (IC50 = 8 nM). Exhibits >100-fold selectivity for hGluN2A (formally hNR2A) containing receptors over hGluN2B (hNR2B). Anticonvulsant in vivo.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Technical Data for PEAQX tetrasodium salt

M. Wt 542.14
Formula C17H13BrN3Na4O5P
Storage Store at -20°C
Purity ≥98% (HPLC)
PubChem ID 76900415
Smiles C[C@@H](C3=CC=C(Br)C=C3)NC(P([O-])([O-])=O)C1=C2C(N=C([O-])C([O-])=N2)=CC=C1.[Na+].[Na+].[Na+].[Na+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PEAQX tetrasodium salt

Solvent Max Conc. mg/mL Max Conc. mM
water 5.42 10 with gentle warming

Preparing Stock Solutions for PEAQX tetrasodium salt

The following data is based on the product molecular weight 542.14. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.45 mL 92.23 mL 184.45 mL
0.5 mM 3.69 mL 18.45 mL 36.89 mL
1 mM 1.84 mL 9.22 mL 18.45 mL
5 mM 0.37 mL 1.84 mL 3.69 mL

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Product Datasheets for PEAQX tetrasodium salt

Certificate of Analysis / Product Datasheet
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References for PEAQX tetrasodium salt

References are publications that support the biological activity of the product.

Auberson et al (2002) 5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition. Bioorg.Med.Chem.Lett. 12 1099 PMID: 11909726

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Keywords: PEAQX tetrasodium salt, PEAQX tetrasodium salt supplier, NVP-AAM, 077, anticonvulsants, potent, selective, NMDA, subtype, antagonists, antagonism, 459836-30-7, 2102348-87-6, Receptors, 5018, Tocris Bioscience

2 Citations for PEAQX tetrasodium salt

Citations are publications that use Tocris products. Selected citations for PEAQX tetrasodium salt include:

Pavel et al (2021) Anticonvulsant Action of GluN2A-Preferring Antagonist PEAQX in Developing Rats. Pharmaceutics 13 PMID: 33808912

Eckart D et al (2022) Ca2+ signaling in postsynaptic neurons: Neuroplastin-65 regulates the interplay between plasma membrane Ca2+ ATPases and ionotropic glutamate receptors. Cell Calcium 106 102623 PMID: 35853264

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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