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PDD 00017272 New
Potent poly (ADP ribose) glycohydrolase (PARG) inhibitor (IC50 values are 4.8 nM in biochemical assay and 9.2 nM in cell based assay).
Sold under license from Cancer Research Technology Ltd (Ximbio).
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||10.63||20 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 531.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||9.4 mL||47.02 mL||94.05 mL|
|1 mM||1.88 mL||9.4 mL||18.81 mL|
|2 mM||0.94 mL||4.7 mL||9.4 mL|
|10 mM||0.19 mL||0.94 mL||1.88 mL|
References are publications that support the biological activity of the product.
Waszkowycz et al (2018) Cell-active small molecule inhibitors of the DNA-damage repair enzyme poly(ADP-ribose) glycohydrolase (PARG): discovery and optimization of orally bioavailable quinazolinedione sulfonamides. J.Med.Chem. 61 10767 PMID: 30403352
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Keywords: PDD 00017272, PDD 00017272 supplier, PDD00017272, PARG, inhibitors, poly, ADP, ribose, glycohydrolase, inhibits, PDDX-004, potent, Other, Hydrolases, 7006, Tocris Bioscience
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