You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Potent poly (ADP ribose) glycohydrolase (PARG) inhibitor (IC50 values are 4.8 nM in biochemical assay and 9.2 nM in cell based assay).
Sold under license from Cancer Research Technology Ltd (Ximbio).
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||10.63||20 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 531.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||9.4 mL||47.02 mL||94.05 mL|
|1 mM||1.88 mL||9.4 mL||18.81 mL|
|2 mM||0.94 mL||4.7 mL||9.4 mL|
|10 mM||0.19 mL||0.94 mL||1.88 mL|
References are publications that support the biological activity of the product.
Waszkowycz et al (2018) Cell-active small molecule inhibitors of the DNA-damage repair enzyme poly(ADP-ribose) glycohydrolase (PARG): discovery and optimization of orally bioavailable quinazolinedione sulfonamides. J.Med.Chem. 61 10767 PMID: 30403352
If you know of a relevant reference for PDD 00017272, please let us know.
View Related Products by Product Action
Keywords: PDD 00017272, PDD 00017272 supplier, PDD00017272, PARG, inhibitors, poly, ADP, ribose, glycohydrolase, inhibits, PDDX-004, potent, Poly(ADP)-ribose, Glycohydrolase, 7006, Tocris Bioscience
Citations for PDD 00017272
Citations are publications that use Tocris products.
Currently there are no citations for PDD 00017272. Do you know of a great paper that uses PDD 00017272 from Tocris? Please let us know.
Reviews for PDD 00017272
There are currently no reviews for this product. Be the first to review PDD 00017272 and earn rewards!
Have you used PDD 00017272?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epigenetics in Cancer Poster
Adapted from the 2015 Cancer Product Guide Edition 3, this poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.