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Biological Activity for PDD 00017272
PDD 00017272 is a potent poly (ADP ribose) glycohydrolase (PARG) inhibitor (IC50 values are 4.8 nM in biochemical assay and 9.2 nM in cell based assay).
Sold under license from Cancer Research Technology Ltd (Ximbio).
Technical Data for PDD 00017272
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PDD 00017272
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||10.63||20 with gentle warming|
Preparing Stock Solutions for PDD 00017272
The following data is based on the product molecular weight 531.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||9.4 mL||47.02 mL||94.05 mL|
|1 mM||1.88 mL||9.4 mL||18.81 mL|
|2 mM||0.94 mL||4.7 mL||9.4 mL|
|10 mM||0.19 mL||0.94 mL||1.88 mL|
References for PDD 00017272
References are publications that support the biological activity of the product.
Waszkowycz et al (2018) Cell-active small molecule inhibitors of the DNA-damage repair enzyme poly(ADP-ribose) glycohydrolase (PARG): discovery and optimization of orally bioavailable quinazolinedione sulfonamides. J.Med.Chem. 61 10767 PMID: 30403352
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Citations for PDD 00017272
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Epigenetics in Cancer Poster
Adapted from the 2015 Cancer Product Guide Edition 3, this poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.