Ozagrel hydrochloride

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Cat.No. 1510 - Ozagrel hydrochloride | C13H12N2O2.HCl | CAS No. 74003-18-2
Description: Selective thromboxane A2 synthetase inhibitor
Alternative Names: OKY 046
Chemical Name: (2E)-3-[4-(1H-Imidazol-1-ylmethyl)phenyl]-2-propenoic acid hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Potent and selective inhibitor of thromboxane (TXA2) synthetase (IC50 = 4 nM). Does not inhibit prostacyclin (PGI2) synthetase, cyclooxygenase or PGE2 isomerase (IC50 > 1 mM). Inhibits platelet aggregation in vitro and arachidonate-induced arterial contraction in vivo.

Technical Data

M. Wt 264.71
Formula C13H12N2O2.HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 74003-18-2
PubChem ID 6438130
InChI Key CWKFWBJJNNPGAM-IPZCTEOASA-N
Smiles Cl[H].OC(=O)\C=C\C1=CC=C(CN2C=CN=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 26.47 100

Preparing Stock Solutions

The following data is based on the product molecular weight 264.71. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.78 mL 18.89 mL 37.78 mL
5 mM 0.76 mL 3.78 mL 7.56 mL
10 mM 0.38 mL 1.89 mL 3.78 mL
50 mM 0.08 mL 0.38 mL 0.76 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Hiraku et al (1986) Pharmacological studies on the TXA2 synthetase inhibitor (E)-3-[p-(1H-imidazol-1ylmethyl)phenyl]-2-propenoic acid (OKY-046). Jpn.J.Pharmacol. 41 393 PMID: 3093741

Naito et al (1983) Effects of thromboxane synthetase inhibitors on aggregation of rabbit platelets. Eur.J.Pharmacol. 91 41 PMID: 6413227

Shinagawa et al (2000) Participation of thromboxane A2 in the cough response in guinea-pigs: antitussive effect of ozagrel. Br.J.Pharmacol. 131 266 PMID: 10991919


If you know of a relevant reference for Ozagrel hydrochloride, please let us know.

Keywords: Selective thromboxane A2 synthetase inhibitors inhibits Thromboxane TP Prostanoid Synthases Synthetases prostaglandins prostacyclins eicosanoids OKY046 OKY 046 Prostanoid Receptors

2 Citations for Ozagrel hydrochloride

Citations are publications that use Tocris products. Selected citations for Ozagrel hydrochloride include:

Wong et al (2009) Cyclooxygenase-2-derived prostaglandin F2alpha mediates endothelium-dependent contractions in the aortae of hamsters with increased impact during aging. Circ Res 104 228 PMID: 19096033

Rancillac et al (2006) Glutamatergic Control of Microvascular Tone by Distinct GABA Neurons in the Cerebellum. Proc Natl Acad Sci U S A 26 6997 PMID: 16807329


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Pathways for Ozagrel hydrochloride

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