Potent and selective inhibitor of thromboxane (TXA2) synthetase (IC50 = 4 nM). Does not inhibit prostacyclin (PGI2) synthetase, cyclooxygenase or PGE2 isomerase (IC50 > 1 mM). Inhibits platelet aggregation in vitro and arachidonate-induced arterial contraction in vivo.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 264.71. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.78 mL||18.89 mL||37.78 mL|
|5 mM||0.76 mL||3.78 mL||7.56 mL|
|10 mM||0.38 mL||1.89 mL||3.78 mL|
|50 mM||0.08 mL||0.38 mL||0.76 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Hiraku et al (1986) Pharmacological studies on the TXA2 synthetase inhibitor (E)-3-[p-(1H-imidazol-1ylmethyl)phenyl]-2-propenoic acid (OKY-046). Jpn.J.Pharmacol. 41 393 PMID: 3093741
Naito et al (1983) Effects of thromboxane synthetase inhibitors on aggregation of rabbit platelets. Eur.J.Pharmacol. 91 41 PMID: 6413227
Shinagawa et al (2000) Participation of thromboxane A2 in the cough response in guinea-pigs: antitussive effect of ozagrel. Br.J.Pharmacol. 131 266 PMID: 10991919
If you know of a relevant reference for Ozagrel hydrochloride, please let us know.
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Keywords: Selective thromboxane A2 synthetase inhibitors inhibits Thromboxane TP Prostanoid Synthases Synthetases prostaglandins prostacyclins eicosanoids OKY046 OKY 046 Prostanoid Receptors
2 Citations for Ozagrel hydrochloride
Citations are publications that use Tocris products. Selected citations for Ozagrel hydrochloride include:
Wong et al (2009) Cyclooxygenase-2-derived prostaglandin F2alpha mediates endothelium-dependent contractions in the aortae of hamsters with increased impact during aging. Circ Res 104 228 PMID: 19096033
Rancillac et al (2006) Glutamatergic Control of Microvascular Tone by Distinct GABA Neurons in the Cerebellum. Proc Natl Acad Sci U S A 26 6997 PMID: 16807329
Do you know of a great paper that uses Ozagrel hydrochloride from Tocris? If so please let us know.
Literature in this Area
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