Orexin B (human)

Pricing Availability Delivery Time Qty
Cat.No. 1456 - Orexin B (human) | Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2 | CAS No. 205640-91-1
Description: Endogenous agonist at OX1 and OX2
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

Endogenous agonist at orexin receptors (Ki values are 420 and 36 nM for OX1 and OX2 receptors, respectively). Stimulates feeding following central administration and may be involved in the control of sleep-wake cycle and other hypothalamic functions. Also neuroprotective for dopaminergic neurons in rat midbrain cultures.

Technical Data

M. Wt 2899.36
Formula C123H212N44O35S
Sequence RSGPPGLQGRLQRLLQASGNHAAGILTM

(Modifications: Met-28 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 205640-91-1
PubChem ID 90479794
InChI Key DHBREICAXZPFDD-WMQZXSDYSA-N
Smiles [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCSC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 2899.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.34 mL 1.72 mL 3.45 mL
5 mM 0.07 mL 0.34 mL 0.69 mL
10 mM 0.03 mL 0.17 mL 0.34 mL
50 mM 0.01 mL 0.03 mL 0.07 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Kilduff and Peyron (2000) The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders. TiNS 23 359 PMID: 10906799

Sakurai et al (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour. Cell 92 573 PMID: 9491897

Smart (1999) Orexins: a new family of neuropeptides. Br.J.Anaesth. 83 695 PMID: 10690128

Guerreiro et al (2015) The sleep-modulating peptide orexin-B protects midbrain dopamine neurons from degeneration, alone or in cooperation with nicotine. Mol.Pharmacol. 87 525 PMID: 25552485


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Keywords: Orexin B (human), supplier, Endogenous, agonists, OX1, OX2, Orexin, Non-Selective, Receptors, OrexinB, (human), Non-selective, Orexin, Non-selective, Orexin, Tocris Bioscience

2 Citations for Orexin B (human)

Citations are publications that use Tocris products. Selected citations for Orexin B (human) include:

Guerreiro et al (2015) The sleep-modulating peptide orexin-B protects midbrain dopamine neurons from degeneration, alone or in cooperation with nicotine. Mol.Pharmacol. 87 525 PMID: 25552485

Malherbe et al (2009) Biochemical and behavioural characterization of EMPA, a novel high-affinity, selective antagonist for the OX(2) receptor. Br.J.Pharmacol. 156 1326 PMID: 19751316


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