OR-486

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Cat.No. 0483 - OR-486 | C6H4N2O6 | CAS No. 7659-29-2
Description: COMT inhibitor
Chemical Name: 3,5-Dinitrocatechol
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (2)

Biological Activity

Potent and selective inhibitor of catechol-O-methyl-transferase.

Technical Data

M. Wt 200.11
Formula C6H4N2O6
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 7659-29-2
PubChem ID 3870203
InChI Key VDCDWNDTNSWDFJ-UHFFFAOYSA-N
Smiles OC1=CC(=CC(=C1O)[N+]([O-])=O)[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 20.01 100
DMSO 20.01 100

Preparing Stock Solutions

The following data is based on the product molecular weight 200.11. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5 mL 24.99 mL 49.97 mL
5 mM 1 mL 5 mL 9.99 mL
10 mM 0.5 mL 2.5 mL 5 mL
50 mM 0.1 mL 0.5 mL 1 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Mannisto and Kaakola (1990) Rationale for selective COMT inhibitors as adjuncts in the drug treatment of Parkinson's disease. Pharmacol.Toxicol. 66 317 PMID: 2196554

Borgulya et al (1989) Catechol-O-methyltransferase-inhibiting pyrocatechol derivatives: synthesis and structure-activity studies. Helv.Chim.Acta 72 952


If you know of a relevant reference for OR-486, please let us know.

View Related Products by Product Action

View all Catechol O-Methyltransferase Inhibitors

Keywords: OR-486, OR-486 supplier, Catechol, O-methyl, transferase, COMT, inhibitors, inhibits, Adrenergic, Related, Compounds, Dopaminergic-Related, O-Methyltransferase, 0483, Tocris Bioscience

2 Citations for OR-486

Citations are publications that use Tocris products. Selected citations for OR-486 include:

Ciszek et al (2016) Persistent catechol-O-methyltransferase-dependent pain is initiated by peripheral β-andrenergic receptors. Anesthesiology 124 1122 PMID: 26950706

Oróstica et al (2014) OE increases cAMP in the oviductal secretory cells through a nongenomic mechanism. Reproduction 148 285 PMID: 25038866


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Literature in this Area

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