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Cat.No. 0483 - OR-486 | C6H4N2O6 | CAS No. 7659-29-2
Description: Catechol O-methyltransferase inhibitor
Chemical Name: 3,5-Dinitrocatechol
Purity: ≥99% (HPLC)
Citations (1)

Biological Activity

Potent and selective inhibitor of catechol-O-methyl-transferase.

Technical Data

M. Wt 200.11
Formula C6H4N2O6
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 7659-29-2
PubChem ID 3870203
Smiles OC1=CC(=CC(=C1O)[N+]([O-])=O)[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 20.01 100
ethanol 20.01 100

Preparing Stock Solutions

The following data is based on the product molecular weight 200.11. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5 mL 24.99 mL 49.97 mL
5 mM 1 mL 5 mL 9.99 mL
10 mM 0.5 mL 2.5 mL 5 mL
50 mM 0.1 mL 0.5 mL 1 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Mannisto and Kaakola (1990) Rationale for selective COMT inhibitors as adjuncts in the drug treatment of Parkinson's disease. Pharmacol.Toxicol. 66 317 PMID: 2196554

Borgulya et al (1989) Catechol-O-methyltransferase-inhibiting pyrocatechol derivatives: synthesis and structure-activity studies. Helv.Chim.Acta 72 952 PMID:

If you know of a relevant reference for OR-486, please let us know.

View Related Products by Product Action

View all Catechol O-Methyltransferase Inhibitors

Keywords: OR-486, supplier, Catechol, O-methyl, transferase, COMT, inhibitors, inhibits, Adrenergic, Related, Compounds, Dopaminergic-Related, Catechol, O-Methyltransferase, Catechol, O-Methyltransferase, Tocris Bioscience

1 Citation for OR-486

Citations are publications that use Tocris products. Selected citations for OR-486 include:

Oróstica et al (2014) Estradiol increases cAMP in the oviductal secretory cells through a nongenomic mechanism. Reproduction 148 285 PMID: 25038866

Do you know of a great paper that uses OR-486 from Tocris? If so please let us know.

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