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Potent and selective inhibitor of catechol-O-methyl-transferase.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 200.11. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||5 mL||24.99 mL||49.97 mL|
|5 mM||1 mL||5 mL||9.99 mL|
|10 mM||0.5 mL||2.5 mL||5 mL|
|50 mM||0.1 mL||0.5 mL||1 mL|
References are publications that support the biological activity of the product.
Mannisto and Kaakola (1990) Rationale for selective COMT inhibitors as adjuncts in the drug treatment of Parkinson's disease. Pharmacol.Toxicol. 66 317 PMID: 2196554
Borgulya et al (1989) Catechol-O-methyltransferase-inhibiting pyrocatechol derivatives: synthesis and structure-activity studies. Helv.Chim.Acta 72 952
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Keywords: OR-486, OR-486 supplier, Catechol, O-methyl, transferase, COMT, inhibitors, inhibits, Adrenergic, Related, Compounds, Dopaminergic-Related, O-Methyltransferase, 0483, Tocris Bioscience
2 Citations for OR-486
Citations are publications that use Tocris products. Selected citations for OR-486 include:
Ciszek et al (2016) Persistent catechol-O-methyltransferase-dependent pain is initiated by peripheral β-andrenergic receptors. Anesthesiology 124 1122 PMID: 26950706
Oróstica et al (2014) OE increases cAMP in the oviductal secretory cells through a nongenomic mechanism. Reproduction 148 285 PMID: 25038866
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.