Octreotide

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Cat.No. 1818 - Octreotide | D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-Thr-ol (Disulfide bridge: 1 - 7) | CAS No. 83150-76-9
Description: sst2, sst3 and sst5 agonist
Alternative Names: SMS 201995, Sandostatin
Datasheet
Citations
Reviews
Literature

Biological Activity

Peptide agonist for sst2, sst3 and sst5 somatostatin receptors. IC50/Kd values (nM) at cloned human somatostatin receptors are: 290 - 1140 (sst1), 0.4 - 2.1 (sst2), 4.4 - 34.5 (sst3), > 1000 (sst4), and 5.6 - 32 (sst5).

Technical Data

M. Wt 1019.24
Formula C49H66N10O10S2
Sequence FCFWKTCT

(Modifications: Phe-1 = D-Phe, Trp-4 = D-Trp, Thr-8 = Thr-ol, Disulfide bridge between 1 - 7)

Storage Desiccate at -20°C
CAS Number 83150-76-9
PubChem ID 90488715
InChI Key DEQANNDTNATYII-XOEBDJBESA-N
Smiles [H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=CC=C2)NC1=O)[C@@H](C)O)C(=O)N[C@H](CO)[C@@H](C)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 1.20 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Hoyer et al (1994) Molecular pharmacology of somatostatin receptors. Naunyn Schmiedebergs Arch.Pharmacol. 350 441 PMID: 7870182

Raynor et al (1993) Cloned somatostatin receptors: identification of subtype-selective peptides and demonstration of high affinity binding to linear peptides. Mol.Pharmacol. 43 838 PMID: 8100350

Hannon et al (2002) Drug design at peptide receptors. Somatostatin receptor ligands. J.Mol.Neurosci. 18 15


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Keywords: Octreotide, Octreotide supplier, sst2, sst3, sst5, agonists, Receptors, Somatostatin, SMS201995, SMS, 201995, Sandostatin, 1818, Tocris Bioscience

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Literature in this Area

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