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Submit ReviewOctreotide
Description: sst2, sst3 and sst5 agonist
Alternative Names: SMS 201995, Sandostatin
Biological Activity for Octreotide
Octreotide is a peptide agonist for sst2, sst3 and sst5 somatostatin receptors. IC50/Kd values (nM) at cloned human somatostatin receptors are: 290 - 1140 (sst1), 0.4 - 2.1 (sst2), 4.4 - 34.5 (sst3), > 1000 (sst4), and 5.6 - 32 (sst5).
Technical Data for Octreotide
| M. Wt | 1019.24 |
| Formula | C49H66N10O10S2 |
| Sequence |
FCFWKTCT (Modifications: Phe-1 = D-Phe, Trp-4 = D-Trp, Thr-8 = Thr-ol, Disulfide bridge between 1 - 7) |
| Storage | Desiccate at -20°C |
| CAS Number | 83150-76-9 |
| PubChem ID | 90488715 |
| InChI Key | DEQANNDTNATYII-XOEBDJBESA-N |
| Smiles | [H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=CC=C2)NC1=O)[C@@H](C)O)C(=O)N[C@H](CO)[C@@H](C)O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Octreotide
| Solubility | Soluble to 1.20 mg/ml in water |
Product Datasheets for Octreotide
References for Octreotide
References are publications that support the biological activity of the product.
Hoyer et al (1994) Molecular pharmacology of somatostatin receptors. Naunyn Schmiedebergs Arch.Pharmacol. 350 441 PMID: 7870182
Raynor et al (1993) Cloned somatostatin receptors: identification of subtype-selective peptides and demonstration of high affinity binding to linear peptides. Mol.Pharmacol. 43 838 PMID: 8100350
Hannon et al (2002) Drug design at peptide receptors. Somatostatin receptor ligands. J.Mol.Neurosci. 18 15
If you know of a relevant reference for Octreotide, please let us know.
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Keywords: Octreotide, Octreotide supplier, sst2, sst3, sst5, agonists, Receptors, Somatostatin, SMS201995, SMS, 201995, Sandostatin, 1818, Tocris Bioscience
Citations for Octreotide
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Currently there are no citations for Octreotide. Do you know of a great paper that uses Octreotide from Tocris? Please let us know.
Reviews for Octreotide
Average Rating: 5 (Based on 1 Review.)
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Octreotide activates cAMP.
By
Kishor Pant on 04/07/2022
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: HepG2, Huh, HuCCT1
It can activate cAMP in the cell via activating somatostatin receptors.
Please mind that it can induce cell growth at low dose and can inhibit the cell growth at higher concentrations.
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