O-2545 hydrochloride

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Cat.No. 2680 - O-2545 hydrochloride | C26H36N2O2.HCl | CAS No. 874745-43-4
Description: High affinity, water-soluble CB1/CB2 agonist
Chemical Name: (6aR,10aR)-6a,7,10,10a-Tetrahydro-3-[5-(1H-imidazol-1-yl)-1,1-dimethylpentyl]-6,6,9-trimethyl-6H-dibenzo[b,d]pyran-1-ol hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

High affinity, water-soluble CB1/CB2 receptor agonist (Ki values are 1.5 and 0.32 nM for CB1 and CB2 receptors respectively). Active in vivo following i.v. and i.c.v. administration.

Licensing Information

Sold under license from VCU-IPF

Technical Data

M. Wt 445.04
Formula C26H36N2O2.HCl
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 874745-43-4
PubChem ID 24848973
InChI Key LSHUCXYFAOTXLT-MUCZFFFMSA-N
Smiles OC1=CC(C(C)(C)CCCCN4C=CN=C4)=CC3=[C@@]1[C@H]2[C@H]([C@@](C)(C)O3)CC=C(C)C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 8.9 20 with gentle warming
ethanol 44.5 100

Preparing Stock Solutions

The following data is based on the product molecular weight 445.04. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.25 mL 11.23 mL 22.47 mL
5 mM 0.45 mL 2.25 mL 4.49 mL
10 mM 0.22 mL 1.12 mL 2.25 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

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References

References are publications that support the biological activity of the product.

Martin et al (2006) Pharmacological characterization of novel water-soluble cannabinoids. J.Pharmacol.Exp.Ther. 318 1230 PMID: 16757541


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Citations for O-2545 hydrochloride

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