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Submit ReviewO-2545 hydrochloride
Description: High affinity, water-soluble CB1/CB2 agonist
Chemical Name: (6aR,10aR)-6a,7,10,10a-Tetrahydro-3-[5-(1H-imidazol-1-yl)-1,1-dimethylpentyl]-6,6,9-trimethyl-6H-dibenzo[b,d]pyran-1-ol hydrochloride
Purity: ≥99% (HPLC)
Biological Activity
High affinity, water-soluble CB1/CB2 receptor agonist (Ki values are 1.5 and 0.32 nM for CB1 and CB2 receptors respectively). Active in vivo following i.v. and i.c.v. administration.
Licensing Information
Sold under license from VCU-IPF
Technical Data
| M. Wt | 445.04 |
| Formula | C26H36N2O2.HCl |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 874745-43-4 |
| PubChem ID | 24848973 |
| InChI Key | LSHUCXYFAOTXLT-MUCZFFFMSA-N |
| Smiles | OC1=CC(C(C)(C)CCCCN4C=CN=C4)=CC3=[C@@]1[C@H]2[C@H]([C@@](C)(C)O3)CC=C(C)C2.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 8.9 | 20 with gentle warming | |
| ethanol | 44.5 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 445.04. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.25 mL | 11.23 mL | 22.47 mL |
| 5 mM | 0.45 mL | 2.25 mL | 4.49 mL |
| 10 mM | 0.22 mL | 1.12 mL | 2.25 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.45 mL |
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References
References are publications that support the biological activity of the product.
Martin et al (2006) Pharmacological characterization of novel water-soluble cannabinoids. J.Pharmacol.Exp.Ther. 318 1230 PMID: 16757541
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Citations for O-2545 hydrochloride
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