Pricing Availability   Qty
Description: Potent GPR55 agonist
Chemical Name: 5-Methyl-4-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-1,3-benzenediol
Purity: ≥97% (HPLC)
Citations (10)
Reviews (2)
Literature (1)

Biological Activity for O-1602

O-1602 is an analog of cannabidiol that is a potent agonist at the GPR55 cannabinoid receptor (EC50 values are 13, > 30000 and > 30000 nM for GPR55, CB1 and CB2 receptors respectively). Induces activation of RhoA, cdc42 and rac1. Increases proliferation of neural stem cells NSCs in vitro and in vivo. Also promotes neurogenesis in vivo.

Technical Data for O-1602

M. Wt 258.36
Formula C17H22O2
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 317321-41-8
PubChem ID 45073499
Smiles C=[C@](C)[C@@H]1CCC(C)=C[C@H]1[C@]2=C(O)C=C(O)C=C2C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for O-1602

Solubility Soluble in methyl acetate (supplied pre-dissolved -10mg/ml)

Product Datasheets for O-1602

Certificate of Analysis / Product Datasheet
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References for O-1602

References are publications that support the biological activity of the product.

Ryberg et al (2007) The orphan receptor GPR55 is a novel cannabinoid receptor. Br.J.Pharmacol. 152 1092 PMID: 17876302

Johns et al (2007) The novel endocannabinoid receptor GPR55 is activated by atypical cannabinoids but does not mediate their vasodilator effects. Br.J.Pharmacol. 152 825 PMID: 17704827

Hill et al (2018) Activation of GPR55 increases neural stem cell proliferation and promotes early adult hippocampal neurogenesis. Br.J.Pharmacol. 175 3407 PMID: 29888782

If you know of a relevant reference for O-1602, please let us know.

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Keywords: O-1602, O-1602 supplier, Potent, GPR55, receptor, agonists, cannabinoids, Receptors, 0-1602, 2797, Tocris Bioscience

10 Citations for O-1602

Citations are publications that use Tocris products. Selected citations for O-1602 include:

Daly et al (2010) Fluorescent ligand binding reveals heterogeneous distribution of adrenoceptors and 'cannabinoid-like' receptors in small arteries. Br J Pharmacol 159 787 PMID: 20136833

Hanlon et al (2016) Modulation of breast cancer cell viability by a cannabinoid receptor 2 agonist, JWH-015, is calcium dependent. Breast Cancer (Dove Med Press) 8 59 PMID: 27186076

Ailte et al (2016) Addition of lysophospholipids with large head groups to cells inhibits Shiga toxin binding Scientific Reports 6 30336 PMID: 27458147

Saliba et al (2018) Anti-neuroinflammatory effects of GPR55 antagonists in LPS-activated primary microglial cells. J Neuroinflammation 15 322 PMID: 30453998

Do you know of a great paper that uses O-1602 from Tocris? Please let us know.

Reviews for O-1602

Average Rating: 5 (Based on 2 Reviews.)

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breast cancer cell viability by a cannabinoid receptor 2 agonist.
By Anonymous on 03/15/2020
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: MCF-7

We used all these compounds which were dissolved in DMSO and added to fresh culture media. Concentration reference paper PMID: 27186076

PMID: 27186076
review image

O-1602 regulates PGE2 release.
By Anonymous on 09/21/2019
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Hippocampus

O-1602 was used to study impact of GPR-55 on prostaglandin E2 release from hippocampal microglial cells. We found that O-1602 causes a clear, albeit not very mighty effect decreasing PGE2 release; concentrations higher than 50 microM did not display a significant difference from effect generated by 50 microM of O-1602.

When supplier's aliquot is added to work solution, product must be obviously sonicated for proper mixture.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cannabinoid Receptor Ligands Scientific Review

Cannabinoid Receptor Ligands Scientific Review

Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.