Discontinued Product

NVP BHG 712 (Cat. No. 4405) has been withdrawn from sale for commercial reasons.
Description: Potent EphB4 kinase inhibitor
Chemical Name: 4-Methyl-3-[[1-methyl-6-(3-pyridinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino]-N-[3-(trifluoromethyl)phenyl]benzamide trifluoroacetate
Purity: ≥98% (HPLC)
Citations (1)
Literature (1)

Biological Activity for NVP BHG 712

Selective inhibitor of EphB4 kinase; exhibits selectivity for EphB4 over more than 40 other kinases in vitro, including FGFR3. Inhibits EphB4 autophosphorylation in transiently transfected HEK 293 cells. Also inhibits VEGF-induced angiogenesis in vivo; thought to inhibit EphB4 forward signaling. Orally active.

Technical Data for NVP BHG 712

M. Wt 617.5
Formula C26H20F3N7O.CF3CO2H
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 940310-85-0
PubChem ID 73332408
Smiles CN1N=CC2=C1N=C(C4=CC=CN=C4)N=C2NC3=CC(C(NC5=CC=CC(C(F)(F)F)=C5)=O)=CC=C3C.OC(C(F)(F)F)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for NVP BHG 712

References are publications that support the biological activity of the product.

Martiny-Baron et al (2010) The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis. Angiogenesis. 13 259 PMID: 20803239

Wnuk et al (2012) Podocyte EphB4 signaling helps recovery from glomerular injury. Kidney Int. 81 1212 PMID: 22398409

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Keywords: NVP BHG 712, NVP BHG 712 supplier, NVPBHG712, EphB4, kinase, inhibitors, inhibits, ephrinB2, EphB2, ephrin, VEGF, angiogenesis, antiangiogenics, ephrins, Eph, Receptors, 4405, Tocris Bioscience

1 Citation for NVP BHG 712

Citations are publications that use Tocris products. Selected citations for NVP BHG 712 include:

Krupke et al (2016) Eph and Ephrin function in dispersal and epithelial insertion of pigmented immunocytes in sea urchin embryos. Elife 5 PMID: 27474796

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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