NVP BHG 712

Pricing Availability Delivery Time Qty
Cat.No. 4405 - NVP BHG 712 | C26H20F3N7O.CF3CO2H | CAS No. 940310-85-0
Description: Potent EphB4 kinase inhibitor
Chemical Name: 4-Methyl-3-[[1-methyl-6-(3-pyridinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino]-N-[3-(trifluoromethyl)phenyl]benzamide trifluoroacetate
Purity: ≥98% (HPLC)
Datasheet
Citations

Biological Activity

Selective inhibitor of EphB4 kinase; exhibits selectivity for EphB4 over more than 40 other kinases in vitro, including FGFR3. Inhibits EphB4 autophosphorylation in transiently transfected HEK 293 cells. Also inhibits VEGF-induced angiogenesis in vivo; thought to inhibit EphB4 forward signaling. Orally active.

Technical Data

M. Wt 617.5
Formula C26H20F3N7O.CF3CO2H
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 940310-85-0
PubChem ID 73332408
InChI Key KCYJGZKWKFCVGC-UHFFFAOYSA-N
Smiles CN1N=CC2=C1N=C(C4=CC=CN=C4)N=C2NC3=CC(C(NC5=CC=CC(C(F)(F)F)=C5)=O)=CC=C3C.OC(C(F)(F)F)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 24.7 40

Preparing Stock Solutions

The following data is based on the product molecular weight 617.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.62 mL 8.1 mL 16.19 mL
5 mM 0.32 mL 1.62 mL 3.24 mL
10 mM 0.16 mL 0.81 mL 1.62 mL
50 mM 0.03 mL 0.16 mL 0.32 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Martiny-Baron et al (2010) The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis. Angiogenesis. 13 259 PMID: 20803239

Wnuk et al (2012) Podocyte EphB4 signaling helps recovery from glomerular injury. Kidney Int. 81 1212 PMID: 22398409


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Keywords: NVPBHG712 EphB4 kinase inhibitors inhibits ephrinB2 EphB2 ephrin VEGF angiogenesis antiangiogenics ephrins Eph Receptors

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