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Description: Cdk1 and cdk2 inhibitor
Chemical Name: 6-(Cyclohexylmethoxy)-9H-purin-2-amine
Purity: ≥99% (HPLC)
Biological Activity for NU 2058
NU 2058 is a cyclin-dependent kinase (cdk) 1 and cdk2 inhibitor (Ki values are 5 and 12 μM respectively). Inhibits growth of human tumor cells in vitro (mean GI50 = 13 μM). Also inhibits DNA topoisomerase II ATPase activity (IC50 = 300 μM).
Technical Data for NU 2058
| M. Wt | 247.3 |
| Formula | C12H17N5O |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 161058-83-9 |
| PubChem ID | 4564 |
| InChI Key | MWGXGTJJAOZBNW-UHFFFAOYSA-N |
| Smiles | NC1=NC(OCC3CCCCC3)=C2C(NC=N2)=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for NU 2058
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.73 | 100 | |
| ethanol | 2.47 | 10 |
Preparing Stock Solutions for NU 2058
The following data is based on the product molecular weight 247.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.04 mL | 20.22 mL | 40.44 mL |
| 5 mM | 0.81 mL | 4.04 mL | 8.09 mL |
| 10 mM | 0.4 mL | 2.02 mL | 4.04 mL |
| 50 mM | 0.08 mL | 0.4 mL | 0.81 mL |
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Product Datasheets for NU 2058
References for NU 2058
References are publications that support the biological activity of the product.
Arris et al (2000) Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles. J.Med.Chem. 43 2797 PMID: 10956187
Knockaert et al (2002) Pharmacological inhibitors of cyclin-dependent kinases. TiPS 23 417 PMID: 12237154
Jensen et al (2005) Substituted purine analogues define a novel structural class of catalytic topoisomerase II inhibitors. Cancer Res. 65 7470 PMID: 16103101
If you know of a relevant reference for NU 2058, please let us know.
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Keywords: NU 2058, NU 2058 supplier, Cdk1, cdk2, Topoisomerase, II, inhibits, inhibitors, Cyclin-Dependent, Protein, Kinases, DNA, Isomerases, NU2058, Cyclin-dependent, Kinase, CDK1, Subfamily, 3135, Tocris Bioscience
1 Citation for NU 2058
Citations are publications that use Tocris products. Selected citations for NU 2058 include:
Goonesekere et al (2014) A meta analysis of pancreatic microarray datasets yields new targets as cancer genes and biomarkers. PLoS One 9 e93046 PMID: 24740004
Do you know of a great paper that uses NU 2058 from Tocris? Please let us know.
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