NU 2058

Discontinued Product

NU 2058 (Cat. No. 3135) has been withdrawn from sale for commercial reasons.
Description: Cdk1 and cdk2 inhibitor
Chemical Name: 6-(Cyclohexylmethoxy)-9H-purin-2-amine
Purity: ≥99% (HPLC)
Citations (1)

Biological Activity for NU 2058

NU 2058 is a cyclin-dependent kinase (cdk) 1 and cdk2 inhibitor (Ki values are 5 and 12 μM respectively). Inhibits growth of human tumor cells in vitro (mean GI50 = 13 μM). Also inhibits DNA topoisomerase II ATPase activity (IC50 = 300 μM).

Technical Data for NU 2058

M. Wt 247.3
Formula C12H17N5O
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 161058-83-9
PubChem ID 4564
Smiles NC1=NC(OCC3CCCCC3)=C2C(NC=N2)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for NU 2058

References are publications that support the biological activity of the product.

Arris et al (2000) Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles. J.Med.Chem. 43 2797 PMID: 10956187

Knockaert et al (2002) Pharmacological inhibitors of cyclin-dependent kinases. TiPS 23 417 PMID: 12237154

Jensen et al (2005) Substituted purine analogues define a novel structural class of catalytic topoisomerase II inhibitors. Cancer Res. 65 7470 PMID: 16103101

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Keywords: NU 2058, NU 2058 supplier, Cdk1, cdk2, Topoisomerase, II, inhibits, inhibitors, Cyclin-Dependent, Protein, Kinases, DNA, Isomerases, NU2058, Cyclin-dependent, Kinase, CDK1, Subfamily, 3135, Tocris Bioscience

1 Citation for NU 2058

Citations are publications that use Tocris products. Selected citations for NU 2058 include:

Goonesekere et al (2014) A meta analysis of pancreatic microarray datasets yields new targets as cancer genes and biomarkers. PLoS One 9 e93046 PMID: 24740004

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