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NSC 625987

Cat. No. 2152 Submit a Review Datasheet / COA / SDS
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Cat.No. 2152 - NSC 625987 | C15H13NO2S | CAS No. 141992-47-4
Description: Cdk4 inhibitor
Chemical Name: 1,4-Dimethoxy-9(10H)-acridinethione
Purity: ≥98% (HPLC)
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for NSC 625987

NSC 625987 is a cyclin-dependent kinase (cdk) 4 inhibitor (IC50 = 0.2 μM at cdk4/cyclin D1). Displays > 500-fold selectivity over cdk2 (IC50 > 100 μM for cdc2/cyclin A, cdk2/cyclin A and cdk2/cyclin E).

Technical Data for NSC 625987

M. Wt 271.33
Formula C15H13NO2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 141992-47-4
PubChem ID 3004085
InChI Key KFAKESMKRPNZTM-UHFFFAOYSA-N
Smiles COC1=C2NC3=CC=CC=C3C(=S)C2=C(OC)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NSC 625987

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 2.71 10
DMSO 27.13 100

Preparing Stock Solutions for NSC 625987

The following data is based on the product molecular weight 271.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.69 mL 18.43 mL 36.86 mL
5 mM 0.74 mL 3.69 mL 7.37 mL
10 mM 0.37 mL 1.84 mL 3.69 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

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Product Datasheets for NSC 625987

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for NSC 625987

References are publications that support the biological activity of the product.

Kubo et al (1999) The p16 status of tumor cell lines identifies small molecule inhibitors specific for cyclin-dependent kinase 4. Clin.Cancer Res. 5 4279 PMID: 10632371

McInnes et al (2004) Structural determinants of CDK4 inhibition and design of selective ATP competitive inhibitors. Chem.Biol. 11 525 PMID: 15123247

If you know of a relevant reference for NSC 625987, please let us know.

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Keywords: NSC 625987, NSC 625987 supplier, Cyclin-dependent, protein, kinases, 4, cdk4, inhibitors, inhibits, Cdk, NSC625987, Kinase, CDK4, Subfamily, 2152, Tocris Bioscience

Citations for NSC 625987

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