NSC 625987
Biological Activity
Cyclin-dependent kinase (cdk) 4 inhibitor (IC50 = 0.2 μM at cdk4/cyclin D1). Displays > 500-fold selectivity over cdk2 (IC50 > 100 μM for cdc2/cyclin A, cdk2/cyclin A and cdk2/cyclin E).
Technical Data
| M. Wt | 271.33 |
| Formula | C15H13NO2S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 141992-47-4 |
| PubChem ID | 3004085 |
| InChI Key | KFAKESMKRPNZTM-UHFFFAOYSA-N |
| Smiles | COC1=C2NC3=CC=CC=C3C(=S)C2=C(OC)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.13 | 100 | |
| ethanol | 2.71 | 10 |
Preparing Stock Solutions
The following data is based on the product molecular weight 271.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.69 mL | 18.43 mL | 36.86 mL |
| 5 mM | 0.74 mL | 3.69 mL | 7.37 mL |
| 10 mM | 0.37 mL | 1.84 mL | 3.69 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.74 mL |
Molarity Calculator
Reconstitution Calculator
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Kubo et al (1999) The p16 status of tumor cell lines identifies small molecule inhibitors specific for cyclin-dependent kinase 4. Clin.Cancer Res. 5 4279 PMID: 10632371
McInnes et al (2004) Structural determinants of CDK4 inhibition and design of selective ATP competitive inhibitors. Chem.Biol. 11 525 PMID: 15123247
If you know of a relevant reference for NSC 625987, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: NSC 625987, supplier, Cyclin-dependent, protein, kinases, 4, cdk4, inhibitors, inhibits, Cdk, NSC625987, Cyclin-dependent, Kinase, Tocris Bioscience
Citations for NSC 625987
Citations are publications that use Tocris products.
Currently there are no citations for NSC 625987. Do you know of a great paper that uses NSC 625987 from Tocris? If so please let us know.
Literature in this Area
Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Angiogenesis
- Invasion and Metastasis
Kinases Product Listing
A collection of over 400 products for kinase research, the listing includes inhibitors of:
- Receptor Tyrosine Kinases
- Protein Kinases A, C, D and G
- PI-3 Kinase, Akt and mTOR
- MAPK Signaling
- Receptor Serine/Threonine Kinases
Neurodegeneration Product Guide
A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:
- Alzheimer's disease
- Parkinson's disease
- Huntington's disease
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.
