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Biological Activity for NSC 625987
NSC 625987 is a cyclin-dependent kinase (cdk) 4 inhibitor (IC50 = 0.2 μM at cdk4/cyclin D1). Displays > 500-fold selectivity over cdk2 (IC50 > 100 μM for cdc2/cyclin A, cdk2/cyclin A and cdk2/cyclin E).
Technical Data for NSC 625987
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for NSC 625987
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for NSC 625987
The following data is based on the product molecular weight 271.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.69 mL||18.43 mL||36.86 mL|
|5 mM||0.74 mL||3.69 mL||7.37 mL|
|10 mM||0.37 mL||1.84 mL||3.69 mL|
|50 mM||0.07 mL||0.37 mL||0.74 mL|
References for NSC 625987
References are publications that support the biological activity of the product.
Kubo et al (1999) The p16 status of tumor cell lines identifies small molecule inhibitors specific for cyclin-dependent kinase 4. Clin.Cancer Res. 5 4279 PMID: 10632371
McInnes et al (2004) Structural determinants of CDK4 inhibition and design of selective ATP competitive inhibitors. Chem.Biol. 11 525 PMID: 15123247
If you know of a relevant reference for NSC 625987, please let us know.
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Keywords: NSC 625987, NSC 625987 supplier, Cyclin-dependent, protein, kinases, 4, cdk4, inhibitors, inhibits, Cdk, NSC625987, Kinase, CDK4, Subfamily, 2152, Tocris Bioscience
Citations for NSC 625987
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