NSC 625987

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Cat.No. 2152 - NSC 625987 | C15H13NO2S | CAS No. 141992-47-4
Description: Cyclin-dependent kinase 4 (cdk4) inhibitor
Chemical Name: 1,4-Dimethoxy-9(10H)-acridinethione
Purity: ≥98% (HPLC)

Biological Activity

Cyclin-dependent kinase (cdk) 4 inhibitor (IC50 = 0.2 μM at cdk4/cyclin D1). Displays > 500-fold selectivity over cdk2 (IC50 > 100 μM for cdc2/cyclin A, cdk2/cyclin A and cdk2/cyclin E).

Technical Data

M. Wt 271.33
Formula C15H13NO2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 141992-47-4
PubChem ID 3004085
Smiles COC1=C2NC3=CC=CC=C3C(=S)C2=C(OC)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 27.13 100
ethanol 2.71 10

Preparing Stock Solutions

The following data is based on the product molecular weight 271.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.69 mL 18.43 mL 36.86 mL
5 mM 0.74 mL 3.69 mL 7.37 mL
10 mM 0.37 mL 1.84 mL 3.69 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Kubo et al (1999) The p16 status of tumor cell lines identifies small molecule inhibitors specific for cyclin-dependent kinase 4. Clin.Cancer Res. 5 4279 PMID: 10632371

McInnes et al (2004) Structural determinants of CDK4 inhibition and design of selective ATP competitive inhibitors. Chem.Biol. 11 525 PMID: 15123247

If you know of a relevant reference for NSC 625987, please let us know.

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Keywords: NSC 625987, supplier, Cyclin-dependent, protein, kinases, 4, cdk4, inhibitors, inhibits, Cdk, NSC625987, Cyclin-dependent, Kinase, Cyclin-dependent, Kinase, Tocris Bioscience

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