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Cat.No. 3512 - NPE-caged-proton | C8H8NNaO6S | CAS No. 1186195-63-0
Description: Caged proton
Alternative Names: NPE-caged-sulfate
Chemical Name: 1-(2-Nitrophenyl)ethyl sulfate sodium salt
Purity: ≥98% (HPLC)

Biological Activity

1-(2-nitrophenyl)ethyl caged proton that releases a proton and a sulfate ion upon photolysis. Generates rapid acidifications down to pH 2 (pH jumps).

Technical Data

M. Wt 269.21
Formula C8H8NNaO6S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1186195-63-0
PubChem ID 57369362
Smiles [O-][N+](C1=C(C(C)OS([O-])(=O)=O)C=CC=C1)=O.[Na+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 26.92 100
water 26.92 100

Preparing Stock Solutions

The following data is based on the product molecular weight 269.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.71 mL 18.57 mL 37.15 mL
5 mM 0.74 mL 3.71 mL 7.43 mL
10 mM 0.37 mL 1.86 mL 3.71 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Barth and Corrie (2002) Characterization of a new caged proton capable of inducing large pH jumps. Biophys.J. 83 2864 PMID: 12414718

Abbruzzetti et al (2005) Kinetics of proton release after flash photolysis of 1-(2-Nitrophenyl)ethyl sulfate (caged sulfate) in aqueous solution. J.Am.Chem.Soc. 127 9865 PMID: 15998092

Peralvarez-Marin et al (2008) Time-resolved infrared spectroscopy of pH-induced aggregation of the Alzheimer Aβ1-28 peptide. J.Mol.Biol. 379 589 PMID: 18462754

If you know of a relevant reference for NPE-caged-proton, please let us know.

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