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Description: Caged proton
Alternative Names: NPE-caged-sulfate
Chemical Name: 1-(2-Nitrophenyl)ethyl sulfate sodium salt
Purity: ≥98% (HPLC)
Reviews (1)

Biological Activity for NPE-caged-proton

NPE-caged-proton is a 1-(2-nitrophenyl)ethyl caged proton that releases a proton and a sulfate ion upon photolysis at 350 - 355 nm. Generates rapid acidifications (pH jumps) down to pH 2.

Technical Data for NPE-caged-proton

M. Wt 269.21
Formula C8H8NNaO6S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1186195-63-0
PubChem ID 57369362
Smiles [O-][N+](C1=C(C(C)OS([O-])(=O)=O)C=CC=C1)=O.[Na+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NPE-caged-proton

Solvent Max Conc. mg/mL Max Conc. mM
water 26.92 100
DMSO 26.92 100

Preparing Stock Solutions for NPE-caged-proton

The following data is based on the product molecular weight 269.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.71 mL 18.57 mL 37.15 mL
5 mM 0.74 mL 3.71 mL 7.43 mL
10 mM 0.37 mL 1.86 mL 3.71 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

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Product Datasheets for NPE-caged-proton

Certificate of Analysis / Product Datasheet
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References for NPE-caged-proton

References are publications that support the biological activity of the product.

Barth and Corrie (2002) Characterization of a new caged proton capable of inducing large pH jumps. Biophys.J. 83 2864 PMID: 12414718

Abbruzzetti et al (2005) Kinetics of proton release after flash photolysis of 1-(2-Nitrophenyl)ethyl sulfate (caged sulfate) in aqueous solution. J.Am.Chem.Soc. 127 9865 PMID: 15998092

Peralvarez-Marin et al (2008) Time-resolved infrared spectroscopy of pH-induced aggregation of the Alzheimer Aβ1-28 peptide. J.Mol.Biol. 379 589 PMID: 18462754

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Citations for NPE-caged-proton

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Reviews for NPE-caged-proton

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NPE Caged-proton.
By Anonymous on 07/17/2020
Species: Human

When photolyzed Caged-proton is supposed to reduce pH; even strong 365nm UV (~1W/cm^2) for 1 second did not show any change in pH

***Bio-Techne Response: Thank you for reviewing our product. We are sorry to hear that this antibody did not perform as expected. We have been in touch with the customer to resolve this issue according to our Product Guarantee and to the customer’s satisfaction. We suggested using a shorter wavelength for photolysis and offered a replacement vial, but we did not receive a response. ***