NPC 15199

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Cat.No. 0675 - NPC 15199 | C21H23NO4 | CAS No. 35661-60-0
Description: Increases intracellular Ca2+ levels
Chemical Name: N-(9-Fluorenylmethoxycarbonyl)-L-leucine
Purity: ≥99% (HPLC)
Datasheet
Citations

Biological Activity

Anti-inflammatory agent; increases intracellular Ca2+ levels.

Technical Data

M. Wt 353.42
Formula C21H23NO4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 35661-60-0
PubChem ID 1549477
InChI Key CBPJQFCAFFNICX-LJQANCHMSA-N
Smiles O=C(N[C@H](CC(C)C)C(O)=O)OCC1C(C=CC=C3)=C3C2=C1C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.34 100mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 353.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.83 mL 14.15 mL 28.29 mL
5 mM 0.57 mL 2.83 mL 5.66 mL
10 mM 0.28 mL 1.41 mL 2.83 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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Reconstitution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Burch et al (1991) N-(Fluorenyl-9-methoxycarbonyl) amino acids, a class of anti-inflammatory agents with a different mechanism of action. Proc.Natl.Acad.Sci.U.S.A. 88 355 PMID: 1824872

Jan et al (2000) NPC-15199, a novel anti-inflammatory agent, mobilizes intracellular Ca2+ in bladder female transitional carcinoma (BFTC) cells. Chin.J.Physiol. 43 29 PMID: 10857466

Miller et al (1993) Guinea pig ileitis is attenuated by the leumidin N-(fluorenyl-9-methoxycarbonyl)leucine (NPC 15199). J.Pharmacol.Exp.Ther. 266 468 PMID: 8392562


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Citations for NPC 15199

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