NPC 15199

Pricing Availability   Qty
Cat.No. 0675 - NPC 15199 | C21H23NO4 | CAS No. 35661-60-0
Description: Increases intracellular Ca2+ levels
Chemical Name: N-(9-Fluorenylmethoxycarbonyl)-L-leucine
Purity: ≥99% (HPLC)

Biological Activity

Anti-inflammatory agent; increases intracellular Ca2+ levels.

Technical Data

M. Wt 353.42
Formula C21H23NO4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 35661-60-0
PubChem ID 1549477
Smiles O=C(N[C@H](CC(C)C)C(O)=O)OCC1C(C=CC=C3)=C3C2=C1C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 35.34 100 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 353.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.83 mL 14.15 mL 28.29 mL
5 mM 0.57 mL 2.83 mL 5.66 mL
10 mM 0.28 mL 1.41 mL 2.83 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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References are publications that support the biological activity of the product.

Burch et al (1991) N-(Fluorenyl-9-methoxycarbonyl) amino acids, a class of anti-inflammatory agents with a different mechanism of action. Proc.Natl.Acad.Sci.U.S.A. 88 355 PMID: 1824872

Jan et al (2000) NPC-15199, a novel anti-inflammatory agent, mobilizes intracellular Ca2+ in bladder female transitional carcinoma (BFTC) cells. Chin.J.Physiol. 43 29 PMID: 10857466

Miller et al (1993) Guinea pig ileitis is attenuated by the leumidin N-(fluorenyl-9-methoxycarbonyl)leucine (NPC 15199). J.Pharmacol.Exp.Ther. 266 468 PMID: 8392562

If you know of a relevant reference for NPC 15199, please let us know.

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