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Cat.No. 0604 - Nicergoline | C24H26BrN3O3 | CAS No. 27848-84-6
Description: α antagonist
Chemical Name: (8β)-10-methoxy-1,6-dimethylergoline-8-methanol 5-bromo-3-pyridine carboxylate ester
Citations (1)

Biological Activity

α-adrenergic, vasodilator. Cognitive enhancer.

Technical Data

M. Wt 484.39
Formula C24H26BrN3O3
Storage Store at RT
CAS Number 27848-84-6
PubChem ID 90479736
Smiles [H][C@](COC(C5=CN=CC(Br)=C5)=O)1C[C@@](C2=CC=CC3C2C(C4)=CN3C)(OC)[C@]4([H])N(C1)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 48.43 100

Preparing Stock Solutions

The following data is based on the product molecular weight 484.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.06 mL 10.32 mL 20.64 mL
5 mM 0.41 mL 2.06 mL 4.13 mL
10 mM 0.21 mL 1.03 mL 2.06 mL
50 mM 0.04 mL 0.21 mL 0.41 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Carfagna et al (1995) Modulation of hippocampal ACh release by chronic nicergoline treatment in freely moving young and aged rats. Neurosci.Lett. 197 195 PMID: 8552297

Carfagna et al (1996) Modulation of phosphoinositide turnover by chronic nicergoline in rat brain. Neurosci.Lett. 209 189 PMID: 8736642

Chopin and Briley (1992) Effects of four non-cholinergic cognitive enhancers in comparison with tacrine and galanthamine on scopolamine-induced amnesia in rats. Psychopharmacology 106 26 PMID: 1738791

Merck Index 12 6580 PMID:

If you know of a relevant reference for Nicergoline, please let us know.

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1 Citation for Nicergoline

Citations are publications that use Tocris products. Selected citations for Nicergoline include:

Woo et al (2007) Neuregulin-1 enhances depolarization-induced GABA release. Neuron 54 599 PMID: 17521572

Do you know of a great paper that uses Nicergoline from Tocris? If so please let us know.

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