Nicergoline

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Cat.No. 0604 - Nicergoline | C24H26BrN3O3 | CAS No. 27848-84-6
Description: α antagonist
Chemical Name: (8β)-10-methoxy-1,6-dimethylergoline-8-methanol 5-bromo-3-pyridine carboxylate ester
Datasheet
Citations (1)
Reviews
Literature (4)

Biological Activity

α-adrenergic, vasodilator. Cognitive enhancer.

Technical Data

M. Wt 484.39
Formula C24H26BrN3O3
Storage Store at RT
CAS Number 27848-84-6
PubChem ID 90479736
InChI Key GCNGMFQQSBSPIJ-XPXYHQFPSA-N
Smiles [H][C@](COC(C5=CN=CC(Br)=C5)=O)1C[C@@](C2=CC=CC3C2C(C4)=CN3C)(OC)[C@]4([H])N(C1)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 48.43 100

Preparing Stock Solutions

The following data is based on the product molecular weight 484.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.06 mL 10.32 mL 20.64 mL
5 mM 0.41 mL 2.06 mL 4.13 mL
10 mM 0.21 mL 1.03 mL 2.06 mL
50 mM 0.04 mL 0.21 mL 0.41 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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References

References are publications that support the biological activity of the product.

Carfagna et al (1995) Modulation of hippocampal ACh release by chronic nicergoline treatment in freely moving young and aged rats. Neurosci.Lett. 197 195 PMID: 8552297

Carfagna et al (1996) Modulation of phosphoinositide turnover by chronic nicergoline in rat brain. Neurosci.Lett. 209 189 PMID: 8736642

Chopin and Briley (1992) Effects of four non-cholinergic cognitive enhancers in comparison with tac. and galanthamine on scopolamine-induced amnesia in rats. Psychopharmacology 106 26 PMID: 1738791

Merck Index 12 6580


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Keywords: Nicergoline, Nicergoline supplier, α-adrenoceptor, alpha-adrenoceptor, a-adrenoceptor, antagonists, α-adrenergic, alpha-adrenergic, a-adrenergic, Receptors, Non-Selective, vasodilator, Non-selective, Adrenergic, Alpha, 0604, Tocris Bioscience

1 Citation for Nicergoline

Citations are publications that use Tocris products. Selected citations for Nicergoline include:

Woo et al (2007) Neuregulin-1 enhances depolarization-induced GABA release. Neuron 54 599 PMID: 17521572


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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