NIBR 189

Discontinued Product

5203 has been discontinued.

View all Orphan 7-TM Receptors products.
Description: Potent and selective EBI2 (GPR183) receptor antagonist
Chemical Name: (2E)-3-(4-Bromophenyl)-1-[4-4-methoxybenzoyl)-1-piperazinyl]-2-propene-1-one
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for NIBR 189

NIBR 189 is a potent and selective EBI2 (GPR183) receptor antagonist (IC50 values are 11 and 15 nM for human and mouse EBI2 receptors respectively). Exhibits selectivity for EBI2 over a panel of other receptors, enzymes and transporters. Blocks oxysterol-induced migration of U937 monocyte cells. Orally bioavailable.

Technical Data for NIBR 189

M. Wt 429.31
Formula C21H21BrN2O3
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1599432-08-2
PubChem ID 36295259
InChI Key OFHXXBRBGWUOHR-NYYWCZLTSA-N
Smiles BrC1=CC=C(/C=C/C(N2CCN(C(C3=CC=C(OC)C=C3)=O)CC2)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for NIBR 189

References are publications that support the biological activity of the product.

Gessier et al (2014) Identification and characterization of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2) receptor. J.Med.Chem. 57 3358 PMID: 24678947

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Citations for NIBR 189

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