NGD 98-2 hydrochloride

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Cat.No. 4315 - NGD 98-2 hydrochloride | C19H24F3N3O3.HCl
Description: High affinity CRF1 antagonist
Chemical Name: N-(1-Ethylpropyl)-3-methoxy-5-[2-methoxy-4-(trifluoromethoxy)phenyl]-6-methyl-2-pyrazinamine hydrochloride
Purity: ≥98% (HPLC)
Literature (3)

Biological Activity for NGD 98-2 hydrochloride

NGD 98-2 hydrochloride is a high affinity antagonist of corticotropin-releasing factor receptor 1 (CRF1) (Ki = 1 nM). Orally available and brain penetrant.

Technical Data for NGD 98-2 hydrochloride

M. Wt 435.87
Formula C19H24F3N3O3.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
PubChem ID 90488929
Smiles CC1=NC(NC(CC)CC)=C(OC)N=C1C2=CC=C(OC(F)(F)F)C=C2OC.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NGD 98-2 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 43.59 100
water 2.18 5 with gentle warming

Preparing Stock Solutions for NGD 98-2 hydrochloride

The following data is based on the product molecular weight 435.87. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.29 mL 11.47 mL 22.94 mL
5 mM 0.46 mL 2.29 mL 4.59 mL
10 mM 0.23 mL 1.15 mL 2.29 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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Product Datasheets for NGD 98-2 hydrochloride

References for NGD 98-2 hydrochloride

References are publications that support the biological activity of the product.

Hodgetts et al (2011) Discovery of N-(1-ethylpropyl)-[3-methoxy-5-(2-methoxy-4-trifluoromethoxyphenyl)-6-methyl-pyrazin-2-yl]amine 59 (NGD 98-2): an orally active cortico. releasing factor-1 (CRF-1) receptor antagonist. J.Med.Chem. 54 4187 PMID: 21618986

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