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NGD 98-2 hydrochloride
Discontinued ProductNGD 98-2 hydrochloride (Cat. No. 4315) has been withdrawn from sale for commercial reasons.
Biological Activity for NGD 98-2 hydrochloride
NGD 98-2 hydrochloride is a high affinity antagonist of corticotropin-releasing factor receptor 1 (CRF1) (Ki = 1 nM). Orally available and brain penetrant.
Technical Data for NGD 98-2 hydrochloride
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for NGD 98-2 hydrochloride
References for NGD 98-2 hydrochloride
References are publications that support the biological activity of the product.
Hodgetts et al (2011) Discovery of N-(1-ethylpropyl)-[3-methoxy-5-(2-methoxy-4-trifluoromethoxyphenyl)-6-methyl-pyrazin-2-yl]amine 59 (NGD 98-2): an orally active cortico. releasing factor-1 (CRF-1) receptor antagonist. J.Med.Chem. 54 4187 PMID: 21618986
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Keywords: NGD 98-2 hydrochloride, NGD 98-2 hydrochloride supplier, NGD982, corticotrophin, corticotropin-release, releasing, factor, receptors, antagonists, CFR-1, CRF1, high, affinity, Receptors, 4315, Tocris Bioscience
Citations for NGD 98-2 hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for NGD 98-2 hydrochloride.
Reviews for NGD 98-2 hydrochloride
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Literature in this Area
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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.