NGD 98-2 hydrochloride

Discontinued Product

NGD 98-2 hydrochloride (Cat. No. 4315) has been withdrawn from sale for commercial reasons.
Description: High affinity CRF1 antagonist
Chemical Name: N-(1-Ethylpropyl)-3-methoxy-5-[2-methoxy-4-(trifluoromethoxy)phenyl]-6-methyl-2-pyrazinamine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity for NGD 98-2 hydrochloride

NGD 98-2 hydrochloride is a high affinity antagonist of corticotropin-releasing factor receptor 1 (CRF1) (Ki = 1 nM). Orally available and brain penetrant.

Technical Data for NGD 98-2 hydrochloride

M. Wt 435.87
Formula C19H24F3N3O3.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
PubChem ID 90488929
InChI Key KUZDADGRZQAQGN-UHFFFAOYSA-N
Smiles CC1=NC(NC(CC)CC)=C(OC)N=C1C2=CC=C(OC(F)(F)F)C=C2OC.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for NGD 98-2 hydrochloride

References for NGD 98-2 hydrochloride

References are publications that support the biological activity of the product.

Hodgetts et al (2011) Discovery of N-(1-ethylpropyl)-[3-methoxy-5-(2-methoxy-4-trifluoromethoxyphenyl)-6-methyl-pyrazin-2-yl]amine 59 (NGD 98-2): an orally active cortico. releasing factor-1 (CRF-1) receptor antagonist. J.Med.Chem. 54 4187 PMID: 21618986

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Keywords: NGD 98-2 hydrochloride, NGD 98-2 hydrochloride supplier, NGD982, corticotrophin, corticotropin-release, releasing, factor, receptors, antagonists, CFR-1, CRF1, high, affinity, Receptors, 4315, Tocris Bioscience

Citations for NGD 98-2 hydrochloride

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Currently there are no citations for NGD 98-2 hydrochloride.

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