NFAT Inhibitor

Pricing Availability Delivery Time Qty
Cat.No. 3930 - NFAT Inhibitor | Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu | CAS No. 249537-73-3
Description: Inhibitor of calcineurin-mediated NFAT activation
Alternative Names: VIVIT peptide
Datasheet
Citations
Literature

Biological Activity

Selective inhibitor of calcineurin-mediated dephosphorylation of nuclear factor of activated T cells (NFAT). Does not disrupt other calcineurin-dependent pathways. Inhibits NFAT activation and NFAT-dependent expression of endogenous cytokine genes in T cells.

Technical Data

M. Wt 1683.94
Formula C75H118N20O22S
Sequence MAGPHPVIVITGPHEE
Storage Store at -20°C
CAS Number 249537-73-3
PubChem ID 16135717
InChI Key QPMHUXBSHGAVGD-MCDIZDEASA-N
Smiles [H]N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1683.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.59 mL 2.97 mL 5.94 mL
5 mM 0.12 mL 0.59 mL 1.19 mL
10 mM 0.06 mL 0.3 mL 0.59 mL
50 mM 0.01 mL 0.06 mL 0.12 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Aramburu et al (1999) Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A. Science 285 2129 PMID: 10497131

Nagamoto-Combs and Combs (2010) Microglial phenotype is regulated by activity of the transcription factor, NFAT (Nuclear Factor of Activated T Cells). J.Neurosci. 30 9641 PMID: 20631193

Roehrl et al (2004) Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules. Proc.Natl.Acad.Sci. 101 7554 PMID:


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Literature in this Area

Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation

Pathways for NFAT Inhibitor

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