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Selective inhibitor of calcineurin-mediated dephosphorylation of nuclear factor of activated T cells (NFAT). Does not disrupt other calcineurin-dependent pathways. Inhibits NFAT activation and NFAT-dependent expression of endogenous cytokine genes in T cells.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 2 mg/ml in water|
References are publications that support the biological activity of the product.
Aramburu et al (1999) Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A. Science 285 2129 PMID: 10497131
Nagamoto-Combs and Combs (2010) Microglial phenotype is regulated by activity of the transcription factor, NFAT (Nuclear Factor of Activated T Cells). J.Neurosci. 30 9641 PMID: 20631193
Roehrl et al (2004) Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules. Proc.Natl.Acad.Sci. 101 7554
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Keywords: NFAT Inhibitor, NFAT Inhibitor supplier, NFAT, Inhibitor, VIVIT, peptide, inhibits, inhibitors, calcineurin, calcineurin-mediated, dephosphorylation, nuclear, factor, of, activated, T, cells, Protein, Ser/Thr, Phosphatases, 3930, Tocris Bioscience
1 Citation for NFAT Inhibitor
Citations are publications that use Tocris products. Selected citations for NFAT Inhibitor include:
Noren et al (2016) Endothelial cells decode VEGF-mediated Ca2+ signaling patterns to produce distinct functional responses. Sci Signal 9 ra20 PMID: 26905425
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