NFAT inhibitor, Cell Permeable

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Cat.No. 5710 - NFAT inhibitor, Cell Permeable | Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Gly-Gly-Gly-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu | CAS No. 592517-80-1
Description: Cell permeable NFAT inhibitor
Alternative Names: 11R-VIVIT
Purity: ≥95% (HPLC)
Reviews (1)
Literature (1)

Biological Activity for NFAT inhibitor, Cell Permeable

NFAT inhibitor, Cell Permeable is a NFAT inhibitor. Inhibits LPS or LPS plus IFN-γ-induced IL-12 p40, IL-12 p70, IL-23 and TNF secretion from bone marrow-derived macrophages (BMDMs). Also attenuates NO production and Nos2 mRNA expression in LPS-stimulated BMDMs. Improves symptoms in a mouse model of colitis. Exhibits immunosuppressive effects; enhances graft survival in mice. Cell permeable.

Technical Data for NFAT inhibitor, Cell Permeable

M. Wt 3573.15
Formula C147H259N67O36S
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 592517-80-1
PubChem ID 16140839
Smiles [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NFAT inhibitor, Cell Permeable

Solubility Soluble to 1 mg/ml in water

Product Datasheets for NFAT inhibitor, Cell Permeable

Certificate of Analysis / Product Datasheet
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References for NFAT inhibitor, Cell Permeable

References are publications that support the biological activity of the product.

Elloumi et al (2012) A cell permeable peptide inhibitor of NFAT inhibits macrophage cytokine expression and ameliorates experimental colitis. PLoS One 7 e34172 PMID: 22479554

Noguchi et al (2004) A new cell-permeable peptide allows successful allogeneic islet transplantation in mice. Nat.Med. 10 305 PMID: 14770176

If you know of a relevant reference for NFAT inhibitor, Cell Permeable, please let us know.

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Keywords: NFAT inhibitor, Cell Permeable, NFAT inhibitor, Cell Permeable supplier, NFAT, inhibitors, inhibits, nuclear, factor, of, activated, T, cells, interleukin, IL-12, IL-23, TNF, anti-inflammatory, inflammation, colitis, 11R-VIVIT, 5710, Tocris Bioscience

Citations for NFAT inhibitor, Cell Permeable

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Reviews for NFAT inhibitor, Cell Permeable

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To determine the effects of a cell permeable NFAT inhibitor in IC-21 cell line.
By Meghan Bradshaw on 02/20/2019
Species: Human
Cell Line/Tissue: IC-21 cell line

NFAT function in macrophages and we worked to determine the effects of a cell permeable NFAT inhibitor in IC-21 cell line.

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Literature in this Area

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Immunology Product Listing

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation