Neuropeptide S (Mouse)

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Description: Endogenous Neuropeptide S receptor agonist
Purity: ≥95% (HPLC)
Datasheet
Citations (3)
Reviews

Biological Activity for Neuropeptide S (Mouse)

Neuropeptide S (Mouse) is a potent endogenous neuropeptide S receptor (NPSR) agonist (EC50 = 3 nM). Induces mobilization of intracellular Ca2+. Increases locomotor activity and wakefulness in mice. Also reduces anxiety-like behavior in mice.

Technical Data for Neuropeptide S (Mouse)

M. Wt 2182.47
Formula C93H156N34O27
Sequence SFRNGVGSGAKKTSFRRAKQ
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 412938-74-0
PubChem ID 54581309
InChI Key XBNIXBCJICZFRR-GYDKITGDSA-N
Smiles [H]N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Neuropeptide S (Mouse)

Solubility Soluble to 2 mg/ml in water

Product Datasheets for Neuropeptide S (Mouse)

Certificate of Analysis / Product Datasheet
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References for Neuropeptide S (Mouse)

References are publications that support the biological activity of the product.

Xu et al (2004) Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects. Neuron 43 487 PMID: 15312648


If you know of a relevant reference for Neuropeptide S (Mouse), please let us know.

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View all Neuropeptide S Receptors Agonists

Keywords: Neuropeptide S (Mouse), Neuropeptide S (Mouse) supplier, Endogenous, neuropeptide, S, receptor, NPSR, agonists, agonism, wakefulness, arousal, anxiety, potent, anxiolytic, Neuropeptide, Receptors, 5857, Tocris Bioscience

3 Citations for Neuropeptide S (Mouse)

Citations are publications that use Tocris products. Selected citations for Neuropeptide S (Mouse) include:

Christopher R et al (2019) Mutant neuropeptide S receptor reduces sleep duration with preserved memory consolidation. Sci Transl Med 11 PMID: 31619542

Maya et al (2022) Familial natural short sleep mutations reduce Alzheimer pathology in mice. iScience 25 103964 PMID: 35496999

Dana et al (2021) Dissociative Effects of Neuropeptide S Receptor Deficiency and Nasal Neuropeptide S Administration on T-Maze Discrimination and Reversal Learning. Pharmaceuticals (Basel) 14 PMID: 34358069


Do you know of a great paper that uses Neuropeptide S (Mouse) from Tocris? Please let us know.

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