Ned K

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Description: NAADP signaling inhibitor
Chemical Name: (1R,3S)-1-[3-[[4-(2-Cyanophenyl)piperazin-1-yl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
Purity: ≥98% (HPLC)

Biological Activity for Ned K

Ned K is a NAADP inhibitor. Prevents Ca2+ oscillations in rat cardiomyocytes in vitro during simulated ischemia and reperfusion, but exhibits no significant effect on Ca2+ sparks. Significantly reduces infarct size in rat cardiac ischemia/reperfusion model in vivo.

Technical Data for Ned K

M. Wt 521.61
Formula C31H31N5O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2250019-90-8
PubChem ID 127021041
Smiles O=C(O)[C@H]1N[C@H](C2=CC=C(OC)C(CN3CCN(C4=CC=CC=C4C#N)CC3)=C2)C5=C(C(C=CC=C6)=C6N5)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ned K

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 26.08 50

Preparing Stock Solutions for Ned K

The following data is based on the product molecular weight 521.61. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.83 mL 19.17 mL 38.34 mL
2.5 mM 0.77 mL 3.83 mL 7.67 mL
5 mM 0.38 mL 1.92 mL 3.83 mL
25 mM 0.08 mL 0.38 mL 0.77 mL

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References for Ned K

References are publications that support the biological activity of the product.

Davidson et al (2015) Inhibition of NAADP signalling on reperfusion protects the heart by preventing lethal calcium oscillations via two-pore channel 1 and opening of the mitochondrial permeability transition pore. Cardiovasc.Res. 108 357 PMID: 26395965

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Keywords: Ned K, Ned K supplier, Nedk, NAADP, signaling, inhibitors, inhibits, nicotinic, acid, adenine, dinucleotide, phosphate, cardioprotectant, calcium, Ca2+, General, Calcium, Signaling, Agents, 5976, Tocris Bioscience

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