NCT 02

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Description: Molecular glue; induces degradation of CCNK and CDK12
Chemical Name: 6,7-Dihydro-N-(5-methyl-2-thiazolyl)-5H-indeno[5,6-b]furan-3-acetamide
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for NCT 02

NCT 02 acts as a molecular glue that induces proteasomal degradation of CCNK and CDK12 in colorectal cancer spheroid cells in vitro (IC50 ≤ 50 μM). NCT 02 also induces apoptosis and the downregulation of genes involved in DNA damage repair.

Technical Data for NCT 02

M. Wt 312.39
Formula C17H16N2O2S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 790245-61-3
PubChem ID 2501755
Smiles CC1=CN=C(S1)NC(CC2=COC3=C2C=C4CCCC4=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NCT 02

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 31.24 100

Preparing Stock Solutions for NCT 02

The following data is based on the product molecular weight 312.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.2 mL 16.01 mL 32.01 mL
5 mM 0.64 mL 3.2 mL 6.4 mL
10 mM 0.32 mL 1.6 mL 3.2 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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References for NCT 02

References are publications that support the biological activity of the product.

Dieter et al (2021) Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer. Cell Rep. 36 109394 PMID: 34289372

If you know of a relevant reference for NCT 02, please let us know.

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Citations for NCT 02

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Literature in this Area

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Targeted Protein Degradation Research Product Guide

Targeted Protein Degradation Research Product Guide

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