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Biological Activity for NCT 02
NCT 02 acts as a molecular glue that induces proteasomal degradation of CCNK and CDK12 in colorectal cancer spheroid cells in vitro (IC50 ≤ 50 μM). NCT 02 also induces apoptosis and the downregulation of genes involved in DNA damage repair.
Technical Data for NCT 02
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for NCT 02
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for NCT 02
The following data is based on the product molecular weight 312.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.2 mL||16.01 mL||32.01 mL|
|5 mM||0.64 mL||3.2 mL||6.4 mL|
|10 mM||0.32 mL||1.6 mL||3.2 mL|
|50 mM||0.06 mL||0.32 mL||0.64 mL|
References for NCT 02
References are publications that support the biological activity of the product.
Dieter et al (2021) Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer. Cell Rep. 36 109394 PMID: 34289372
If you know of a relevant reference for NCT 02, please let us know.
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Keywords: NCT 02, NCT 02 supplier, NCT02, molecular, glue, proteasomal, degraders, inhibitors, inhibit, inhibition, apoptosis, ubiquitination, CCNK, cyclin, K, CDK12, Molecular, Glues, Transcriptional, CDKs, 7551, Tocris Bioscience
Citations for NCT 02
Citations are publications that use Tocris products.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Targeted Protein Degradation Research Product Guide
This brochure highlights the tools and services available from Bio-Techne to support Targeted Protein Degradation research, including:
- Active Degraders
- TAG Degradation Platform
- Degrader Building Blocks
- Ubiquitin-Proteasome System Proteins
- Assays for Protein Degradation