NBI 31772

Pricing Availability   Qty
Description: High affinity insulin-like growth factor-I binding protein IGFBP inhibitor
Chemical Name: 1-(3,4-Dihydroxybenzoyl)-6,7-dihydroxy-3-isoquinolinecarboxylic acid
Purity: ≥98% (HPLC)
Citations (2)
Literature (2)
Pathways (1)

Biological Activity for NBI 31772

NBI 31772 is a high affinity insulin-like growth factor-1 binding protein (IGFBP) inhibitor (Ki values are 1 - 24 nM for all six human subtypes). Displaces insulin-like growth factor-1 (IGF-1) from the IGF-1:IGFBP complex and suppresses IGF1-induced proliferation of 3T3 fibroblasts. Also increases cardiomyocyte proliferation in vivo.

Technical Data for NBI 31772

M. Wt 341.27
Formula C17H11NO7
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 374620-70-9
PubChem ID 54684689
Smiles O=C(C3=CC=C(O)C(O)=C3)C2=NC(C(O)=O)=CC1=CC(O)=C(O)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NBI 31772

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 34.13 100

Preparing Stock Solutions for NBI 31772

The following data is based on the product molecular weight 341.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.93 mL 14.65 mL 29.3 mL
5 mM 0.59 mL 2.93 mL 5.86 mL
10 mM 0.29 mL 1.47 mL 2.93 mL
50 mM 0.06 mL 0.29 mL 0.59 mL

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Product Datasheets for NBI 31772

Certificate of Analysis / Product Datasheet
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References for NBI 31772

References are publications that support the biological activity of the product.

Chen et al (2001) Discovery of a series of nonpeptide small molecules that inhibit the binding of Ins-like growth factor (IGF) to IGF-binding proteins. J.Med.Chem. 44 4001 PMID: 11689087

Choi et al (2013) In vivo monitoring of cardiomyocyte proliferation to identify chemical modifiers of heart regeneration. Development. 140 660 PMID: 23293297

If you know of a relevant reference for NBI 31772, please let us know.

Keywords: NBI 31772, NBI 31772 supplier, NBI31772, High, affinity, insulin-like, growth, factor-1, binding, proteins, inhibitors, inhibits, IGFBP-3, IGF-1, cardiomyocytes, Insulin, and, Receptors, Insulin-like, 5192, Tocris Bioscience

2 Citations for NBI 31772

Citations are publications that use Tocris products. Selected citations for NBI 31772 include:

Ichijo et al (2017) Tbx3-dependent amplifying stem cell progeny drives interfollicular epidermal expansion during pregnancy and regeneration. Nat Commun 8 508 PMID: 28894084

Markus et al (2017) An O-Glycosylation of Fibronectin Mediates Hepatic Osteodystrophy Through α4β1 Integrin. J Bone Miner Res 32 70-81 PMID: 27427791

Do you know of a great paper that uses NBI 31772 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Pathways for NBI 31772

Insulin Signaling Pathway

Insulin Signaling Pathway

Signaling through the insulin pathway is fundamental for the regulation of intracellular glucose levels. This pathway can become dysregulated in diabetes.