NB-caged Tyrosine hydrochloride

Pricing Availability   Qty
Cat.No. 6121 - NB-caged Tyrosine hydrochloride | C16H16N2O5.HCl | CAS No. 207727-86-4
Description: ortho-nitrobenzyl caged L- tyrosine
Alternative Names: ONBY
Chemical Name: O-[(2-Nitrophenyl)methyl]-L-tyrosine hydrochloride
Purity: ≥97% (HPLC)
Literature (1)

Biological Activity

L-Tyrosine caged with photosensitive ortho-nitrobenzyl side chain. Rapidly releases tyrosine when photolyzed (300-350 nm excitation). Is readily incorporated into E.coli proteins via inclusion in growth media.

Technical Data

M. Wt 352.77
Formula C16H16N2O5.HCl
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 207727-86-4
PubChem ID 53393436
Smiles N[C@H](C(O)=O)CC1=CC=C(C=C1)OCC2=C([N+]([O-])=O)C=CC=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 35.28 100

Preparing Stock Solutions

The following data is based on the product molecular weight 352.77. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.83 mL 14.17 mL 28.35 mL
5 mM 0.57 mL 2.83 mL 5.67 mL
10 mM 0.28 mL 1.42 mL 2.83 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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References are publications that support the biological activity of the product.

Miller et al (1998) Flash decaging of tyrosine sidechains in an ion channel. Neuron. 20 619 PMID: 9581754

Monk et al (2017) Rapid and inexpensive evaluation of nonstandard amino acid incorporation in Escherichia coli. ACS.Synth.Biol. 6 45 PMID: 27648665

Wang et al (2019) Time-resolved protein activation by proximal decaging in living systems. Nature 569 509 PMID: 31068699

If you know of a relevant reference for NB-caged Tyrosine hydrochloride, please let us know.

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Citations for NB-caged Tyrosine hydrochloride

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