Selective, non-competitive NMDA receptor antagonist (IC50 = 5 μM); binds to the receptor-associated ion channel and prevents glutamate-induced Ca2+ influx. Displays neuroprotective activity in vivo. Brain-penetrant.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 304.82. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.28 mL||16.4 mL||32.81 mL|
|5 mM||0.66 mL||3.28 mL||6.56 mL|
|10 mM||0.33 mL||1.64 mL||3.28 mL|
|50 mM||0.07 mL||0.33 mL||0.66 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Planells-Cases et al (2002) A novel N-methyl-D-aspartate receptor open channel blocker with in vivo neuroprotectant activity. J.Pharmacol.Exp.Ther. 302 163 PMID: 12065713
If you know of a relevant reference for N20C hydrochloride, please let us know.
Keywords: Non-competitive NMDA receptor open-channel blockers glutamate Receptors N-Methyl-D-Aspartate iGluR Ionotropic NMDA Receptors
1 Citation for N20C hydrochloride
Citations are publications that use Tocris products. Selected citations for N20C hydrochloride include:
Roy et al (2014) Enhancement of morphological plasticity in hippocampal neurons by a physically modified saline via phosphatidylinositol-3 kinase. J Biol Chem 9 e101883 PMID: 25007337
Do you know of a great paper that uses N20C hydrochloride from Tocris? If so please let us know.
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