N1,N12-Diethylspermine tetrahydrochloride

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Cat.No. 0500 - N1,N12-Diethylspermine tetrahydrochloride | C14H34N4.4HCl | CAS No. 113812-15-0
Description: Polyamine synthase inhibitor

Biological Activity

Powerful antineoplastic agent in cultured cells and animal tumors (IC50 = 0.2 μM in L1210 cells). Inhibitor of polyamine synthases. Suppressor of mitochondrial DNA synthesis.

Technical Data

M. Wt 404.29
Formula C14H34N4.4HCl
Storage Store at RT
CAS Number 113812-15-0
PubChem ID 11750054

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 404.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.47 mL 12.37 mL 24.73 mL
5 mM 0.49 mL 2.47 mL 4.95 mL
10 mM 0.25 mL 1.24 mL 2.47 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Bergeron et al (1988) Synthetic polyamine analogues as antineoplastics. J.Med.Chem. 31 1183 PMID: 3373487

Bergeron et al (2005) Synthesis and bioloigcal evaluation of aminopolyamines. J.Med.Chem. 48 3099 PMID: 15857111

Porter et al (1990) Combined regulation of arginine and S-adenosylmethionine decarboxylases by spermine and the spermine analogue N1,N12-bis(ethyl)spermine. Biochem.J. 268 207 PMID: 2344358

Vertino et al (1991) Selective cellular depletion of mitochondrial DNA by the polyamine analog N1,N12-bis(ethyl)spermine and its relationship to polyamine structure and function. Mol.Pharmacol. 39 487 PMID: 2017149

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Keywords: N1,N12-Diethylspermine tetrahydrochloride, supplier, Polyamine, synthase, inhibitors, inhibits, Synthases, Synthetases, Other, Synthases/Synthetases, Other, Synthases/Synthetases, Tocris Bioscience

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