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N1,N12-Diethylspermine tetrahydrochloride is a powerful antineoplastic agent in cultured cells and animal tumors (IC50 = 0.2 μM in L1210 cells). Inhibitor of polyamine synthases. Suppressor of mitochondrial DNA synthesis.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 404.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.47 mL||12.37 mL||24.73 mL|
|5 mM||0.49 mL||2.47 mL||4.95 mL|
|10 mM||0.25 mL||1.24 mL||2.47 mL|
|50 mM||0.05 mL||0.25 mL||0.49 mL|
References are publications that support the biological activity of the product.
Bergeron et al (1988) Synthetic polyamine analogues as antineoplastics. J.Med.Chem. 31 1183 PMID: 3373487
Bergeron et al (2005) Synthesis and bioloigcal evaluation of aminopolyamines. J.Med.Chem. 48 3099 PMID: 15857111
Porter et al (1990) Combined regulation of arginine and S-adenosylmethionine decarboxylases by spermine and the spermine analogue N1,N12-bis(ethyl)spermine. Biochem.J. 268 207 PMID: 2344358
Vertino et al (1991) Selective cellular depletion of mitochondrial DNA by the polyamine analog N1,N12-bis(ethyl)spermine and its relationship to polyamine structure and function. Mol.Pharmacol. 39 487 PMID: 2017149
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Keywords: N1,N12-Diethylspermine tetrahydrochloride, N1,N12-Diethylspermine tetrahydrochloride supplier, Polyamine, synthase, inhibitors, inhibits, Synthases, Synthetases, Other, Synthases/Synthetases, 0500, Tocris Bioscience
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