Powerful antineoplastic agent in cultured cells and animal tumors (IC50 = 0.2 μM in L1210 cells). Inhibitor of polyamine synthases. Suppressor of mitochondrial DNA synthesis.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 100 mM in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 404.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.47 mL||12.37 mL||24.73 mL|
|5 mM||0.49 mL||2.47 mL||4.95 mL|
|10 mM||0.25 mL||1.24 mL||2.47 mL|
|50 mM||0.05 mL||0.25 mL||0.49 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Bergeron et al (1988) Synthetic polyamine analogues as antineoplastics. J.Med.Chem. 31 1183 PMID: 3373487
Bergeron et al (2005) Synthesis and bioloigcal evaluation of aminopolyamines. J.Med.Chem. 48 3099 PMID: 15857111
Porter et al (1990) Combined regulation of arginine and S-adenosylmethionine decarboxylases by spermine and the spermine analogue N1,N12-bis(ethyl)spermine. Biochem.J. 268 207 PMID: 2344358
Vertino et al (1991) Selective cellular depletion of mitochondrial DNA by the polyamine analog N1,N12-bis(ethyl)spermine and its relationship to polyamine structure and function. Mol.Pharmacol. 39 487 PMID: 2017149
If you know of a relevant reference for N1,N12-Diethylspermine tetrahydrochloride, please let us know.
View Related Products by Product Action
Keywords: N1,N12-Diethylspermine tetrahydrochloride, supplier, Polyamine, synthase, inhibitors, inhibits, Synthases, Synthetases, Other, Synthases/Synthetases, Tocris Bioscience
Citations for N1,N12-Diethylspermine tetrahydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for N1,N12-Diethylspermine tetrahydrochloride. Do you know of a great paper that uses N1,N12-Diethylspermine tetrahydrochloride from Tocris? If so please let us know.