Highly potent inducer of spermidine/spermine N1-acetyltransferase, able to increase enzyme activity 200-1000 fold.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 390.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.56 mL||12.81 mL||25.62 mL|
|5 mM||0.51 mL||2.56 mL||5.12 mL|
|10 mM||0.26 mL||1.28 mL||2.56 mL|
|50 mM||0.05 mL||0.26 mL||0.51 mL|
References are publications that support the products' biological activity.
Bernacki et al (1992) Antitumour activity of N1,N12-bis(ethyl)spermine homologs against human MALME-3 melanoma xenografts. Cancer Res. 52 2424 PMID: 1568212
Fogel-Petrovic et al (1997) Structural basis for differential induction of spermidine/spermine N1-acetyltransferase activity by novel spermine analogs. Mol.Pharmacol. 52 69 PMID: 9224814
Libby et al (1991) Characterization of human spermidine spermine N1-acetyltransferase purified from cultured melanoma cells. Arch.Biochem.Biophys. 284 238 PMID: 1989509
Porter et al (1993) Antitumour activity of N1,N12-bis(ethyl)-norspermine against human melanoma xenografts and possible biochemical correlates of drug action. Cancer Res. 53 581 PMID: 8425191
If you know of a relevant reference for N1,N11-Diethylnorspermine tetrahydrochloride, please let us know.
Keywords: N1,N11-Diethylnorspermine tetrahydrochloride, supplier, Spermine, spermidine, N1-acetyltransferase, potentiator, Acyltransferases, Transferases, Enzyme, Substrates, /, Activators, Other, Transferases, Other, Transferases, Tocris Bioscience
Citations for N1,N11-Diethylnorspermine tetrahydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for N1,N11-Diethylnorspermine tetrahydrochloride. Do you know of a great paper that uses N1,N11-Diethylnorspermine tetrahydrochloride from Tocris? If so please let us know.
Reviews for N1,N11-Diethylnorspermine tetrahydrochloride
There are currently no reviews for this product. Be the first to review N1,N11-Diethylnorspermine tetrahydrochloride and earn rewards!
Have you used N1,N11-Diethylnorspermine tetrahydrochloride?
Submit a review and receive an Amazon gift card.
$10US/$10CAN/€7/£6 gift card for a review without an image
$25US/$25CAN/€18/£15 gift card for a review with an image
*Offer only valid in the USA / Canada, UK and EuropeSubmit a Review
Literature in this Area
New Product Guide (Spring/Summer 2017)
Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.
- 7-TM Receptors
- Enzyme-Linked Receptors
- Ion Channels
- Nuclear Receptors
- Cell Metabolism
- Fluorescent Imaging
- Signal Transduction
- Stem Cells