N1,N11-Diethylnorspermine tetrahydrochloride

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Description: Spermine and spermidine acetyltransferase potentiator
Chemical Name: N,N'-bis[3-(Ethylamino)propyl]-1,3-propanediamine tetrahydrochloride
Citations (1)

Biological Activity

N1,N11-Diethylnorspermine tetrahydrochloride is a highly potent inducer of spermidine/spermine N1-acetyltransferase, able to increase enzyme activity 200-1000 fold.

Technical Data

M. Wt 390.27
Formula C13H32N4.4HCl
Storage Store at RT
CAS Number 156886-85-0
PubChem ID 11501988

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 39.03 100

Preparing Stock Solutions

The following data is based on the product molecular weight 390.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

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Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.56 mL 12.81 mL 25.62 mL
5 mM 0.51 mL 2.56 mL 5.12 mL
10 mM 0.26 mL 1.28 mL 2.56 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Bernacki et al (1992) Antitumour activity of N1,N12-bis(ethyl)spermine homologs against human MALME-3 melanoma xenografts. Cancer Res. 52 2424 PMID: 1568212

Fogel-Petrovic et al (1997) Structural basis for differential induction of spermidine/spermine N1-acetyltransferase activity by novel spermine analogs. Mol.Pharmacol. 52 69 PMID: 9224814

Libby et al (1991) Characterization of human spermidine spermine N1-acetyltransferase purified from cultured melanoma cells. Arch.Biochem.Biophys. 284 238 PMID: 1989509

Porter et al (1993) Antitumour activity of N1,N12-bis(ethyl)-norspermine against human melanoma xenografts and possible biochemical correlates of drug action. Cancer Res. 53 581 PMID: 8425191

If you know of a relevant reference for N1,N11-Diethylnorspermine tetrahydrochloride, please let us know.

Keywords: N1,N11-Diethylnorspermine tetrahydrochloride, N1,N11-Diethylnorspermine tetrahydrochloride supplier, Spermine, spermidine, N1-acetyltransferase, potentiator, Acyltransferases, Transferases, Enzyme, Substrates, /, Activators, Other, 0468, Tocris Bioscience

1 Citation for N1,N11-Diethylnorspermine tetrahydrochloride

Citations are publications that use Tocris products. Selected citations for N1,N11-Diethylnorspermine tetrahydrochloride include:

Sandusky-Beltran et al (2019) Spermidine/spermine-N1-acetyltransferase ablation impacts tauopathy-induced polyamine stress response. Alzheimers Res Ther 11 58 PMID: 31253191

Do you know of a great paper that uses N1,N11-Diethylnorspermine tetrahydrochloride from Tocris? Please let us know.

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