MYX 1715

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Description: N-myristoyltransferase (NMT) inhibitor
Chemical Name: 4-[2-[2-[3-(2-Aminoethyl)imidazo[1,2-a]pyridin-6-yl]-5-chlorophenoxy]ethyl]-N,N,1,5-tetramethyl-1H-pyrazole-3-carboxamide dihydrochloride
Purity: ≥98% (HPLC)

Biological Activity for MYX 1715

MYX 1715 is a N-myristoyltransferase inhibitor (NMT). MYX 1715 selectively kills senescent cancer cells in mouse models of paediatric pituitary tumors and liver cancer, and prevents tumor growth in mouse xenografts. In mouse models of idiopathic pulmonary fibrosis (IPF) and NASH, MYX 1715 reduces both lung and liver fibrosis, and decreases inflammation and steatosis.

Technical Data for MYX 1715

M. Wt 553.91
Formula C25H29ClN6O2.2HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
Smiles O=C(N(C)C)C1=NN(C)C(C)=C1CCOC2=C(C3=CN4C(CCN)=CN=C4C=C3)C=CC(Cl)=C2.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MYX 1715

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 55.39 100
water 55.39 100

Preparing Stock Solutions for MYX 1715

The following data is based on the product molecular weight 553.91. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.81 mL 9.03 mL 18.05 mL
5 mM 0.36 mL 1.81 mL 3.61 mL
10 mM 0.18 mL 0.9 mL 1.81 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

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References for MYX 1715

References are publications that support the biological activity of the product.

McHugh et al (2023) COPI vesicle formation and N-myristoylation are targetable vulnerabilities of senescent cells. Nat.Cell Biol. 25 1804 PMID: 38012402

If you know of a relevant reference for MYX 1715, please let us know.

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Keywords: MYX 1715, MYX 1715 supplier, MYX1715, senescent, cancer, cells, tumor, steatosis, xenograft, non-alcoholic, steatohepatitis, idiopathic, pulmonary, fibrosis, in, vivo, IMP1320, Other, Transferases, 8109, Tocris Bioscience

Citations for MYX 1715

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