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Submit ReviewMuramyl Dipeptide
Description: Activates NOD2 receptors
Chemical Name: N-Acetylmuramoyl-L-alanyl-D-α-glutamine
Purity: ≥98% (HPLC)
Biological Activity
Bacterial peptidoglycan fragment that activates NOD2 receptors. Induces polarization of proinflammatory Ly6Chigh into Ly6Clow patrolling monocytes.
Technical Data
| M. Wt | 492.48 |
| Formula | C19H32N4O11 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 53678-77-6 |
| PubChem ID | 451714 |
| InChI Key | BSOQXXWZTUDTEL-ZUYCGGNHSA-N |
| Smiles | C[C@@H](O[C@@H]1[C@@H](NC(C)=O)C(O)O[C@H](CO)[C@H]1O)C(N[C@@H](C)C(N[C@@H](C(N)=O)CCC(O)=O)=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 49.25 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 492.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.03 mL | 10.15 mL | 20.31 mL |
| 5 mM | 0.41 mL | 2.03 mL | 4.06 mL |
| 10 mM | 0.2 mL | 1.02 mL | 2.03 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.41 mL |
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Product Datasheets
References
References are publications that support the biological activity of the product.
Lessard et al (2017) Triggering of NOD2 receptor converts inflammatory Ly6Chigh into Ly6Clow monocytes with patrolling properties. Cell Rep. 20 1830 PMID: 28834747
If you know of a relevant reference for Muramyl Dipeptide, please let us know.
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Keywords: Muramyl Dipeptide, Muramyl Dipeptide supplier, NOD2, nod-like, receptors, activates, activators, bacterial, peptidoglycan, innate, immunity, pattern, recognition, Inflammasomes, 6366, Tocris Bioscience
Citations for Muramyl Dipeptide
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