MS049 oxalate salt

Discontinued Product

MS049 oxalate salt (Cat. No. 5685) has been withdrawn from sale for commercial reasons.
Description: Potent and selective PRMT4 and PRMT6 inhibitor
Chemical Name: N-Methyl-4-(phenylmethoxy)-1-piperidineethanamine oxalate salt
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for MS049 oxalate salt

Potent and selective PRMT4 and PRMT6 inhibitor (IC50 values are 44 and 63 nM, respectively). Reduces Med12me2a and H3R2me2a levels in HEK293 cells in vitro.

To request the negative control for MS049, please fill out the MS049N request form on the SGC website.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the MS049 probe summary on the SGC website.

Technical Data for MS049 oxalate salt

M. Wt 338.4
Formula C15H24N2O.C2H2O4
Storage Desiccate at RT
Purity ≥98% (HPLC)
PubChem ID 121513883

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for MS049 oxalate salt

References for MS049 oxalate salt

References are publications that support the biological activity of the product.

Shen et al (2016) Discovery of a potent, selective, and cell-active dual inhibitor of protein arginine methyltransferase 4 and protein arginine methyltransferase 6. J.Med.Chem. 59 9124 PMID: 27584694

Scheer et al (2019) A chemical biology toolbox to study protein methyltransferases and epigenetic signaling. Nat.Commun. 10 19 PMID: 30604761

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Keywords: MS049 oxalate salt, MS049 oxalate salt supplier, PRMT4, PRMT6, protein, arginine, methyltransferases, inhibits, inhibitors, 1502816-23-0, Protein, Arginine, Methyltransferases, 5685, Tocris Bioscience

Citations for MS049 oxalate salt

Citations are publications that use Tocris products.

Currently there are no citations for MS049 oxalate salt.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Epigenetics Scientific Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.