MS 023 dihydrochloride
Potent and selective type I PRMT inhibitor (IC50 values are 8, 8, 30, 83 and 119 nM for PRMT6, PRMT8, PRMT1, PRMT4 and PRMT3, respectively). Exhibits no significant activity against type II and III PRMTs, PKMTs, DNMTs, KDMs and reader proteins. Reduces global arginine asymmetric dimethylation levels in vitro.
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the MS023 probe summary on the SGC website.
External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of MS023 is reviewed on the chemical probes website.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 360.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.78 mL||13.88 mL||27.75 mL|
|5 mM||0.56 mL||2.78 mL||5.55 mL|
|10 mM||0.28 mL||1.39 mL||2.78 mL|
|50 mM||0.06 mL||0.28 mL||0.56 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Eram et al (2016) A potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases. ACS Chem.Biol. 11 772 PMID: 26598975
If you know of a relevant reference for MS 023 dihydrochloride, please let us know.
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Keywords: MS023 dihydrochloride potent Type-1 selective PRMT inhibitors inhibits PRMT6 PRMT8 PRMT1 PRMT4 PRMT3 Protein Arginine Methyltransferases
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Literature in this Area
Epigenetics Scientific Review
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Epigenetics Research Bulletin
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