MNI-caged-D-aspartate

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Cat.No. 2277 - MNI-caged-D-aspartate | C13H15N3O6 | CAS No. 845555-94-4
Description: Caged D-aspartate; NMDA agonist
Alternative Names: 4-Methoxy-7-nitroindolinyl-caged-D-aspartate
Chemical Name: (R)-α-Amino-2,3-dihydro-4-methoxy-7-nitro-γ-oxo-1H-indole-1-butanoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

D-aspartate caged with the photosensitive 4-methoxy-7-nitroindolinyl group. Photolyzed by UV light with a quantum efficiency of 0.09 at pH 7.4. Agonist at NMDA receptors and EAAT substrate.

Licensing Information

Sold under license from the UK Medical Research Council

Technical Data

M. Wt 309.27
Formula C13H15N3O6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 845555-94-4
PubChem ID 56972233
InChI Key ATNVWKDWOLQDKH-MRVPVSSYSA-N
Smiles O=C(C[C@H](C(O)=O)N)N2C1=C([N+]([O-])=O)C=CC(OC)=C1CC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.09 10
water 1.55 5

Preparing Stock Solutions

The following data is based on the product molecular weight 309.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.23 mL 16.17 mL 32.33 mL
5 mM 0.65 mL 3.23 mL 6.47 mL
10 mM 0.32 mL 1.62 mL 3.23 mL
50 mM 0.06 mL 0.32 mL 0.65 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Huang et al (2005) Synthesis and characterization of 4-methoxy-7-nitroindolinyl-D-aspartate, a caged compound for selective activation of glutamate transporters and N-methyl-D-aspartate receptors in brain tissue. Biochemistry 44 3316 PMID: 15736942


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Citations for MNI-caged-D-aspartate

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