ML 354

Pricing Availability Delivery Time Qty
Cat.No. 5387 - ML 354 | C16H14N2O3 | CAS No. 89159-60-4
Description: Selective PAR4 antagonist
Chemical Name: 1-Methyl-5-nitro-3-phenyl-1H-indole-2-methanol
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective PAR4 antagonist (IC50 = 140 nM). Exhibits 70-fold selectivity for PAR4 over PAR1.

Technical Data

M. Wt 282.29
Formula C16H14N2O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 89159-60-4
PubChem ID 752812
InChI Key GNJUKVGDCUKDLF-UHFFFAOYSA-N
Smiles CN2C1=CC=C([N+]([O-])=O)C=C1C(C3=CC=CC=C3)=C2CO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.23 100
ethanol 2.82 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 282.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.54 mL 17.71 mL 35.42 mL
5 mM 0.71 mL 3.54 mL 7.08 mL
10 mM 0.35 mL 1.77 mL 3.54 mL
50 mM 0.07 mL 0.35 mL 0.71 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Wen et al (2014) Substituted indoles as selective protease activated receptor 4 (PAR4) antagonists: Discovery and SAR of ML354. Bioorg.Med.Chem.Lett. 24 4708 PMID: 25176330


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Keywords: ML354 SID161004646 VU0099704 selective protease activated receptors PAR4 antagonists Protease-Activated Receptors

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Literature in this Area

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Pathways for ML 354

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