ML 354

Pricing Availability   Qty
Description: Selective PAR4 antagonist
Chemical Name: 1-Methyl-5-nitro-3-phenyl-1H-indole-2-methanol
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity for ML 354

ML 354 is a selective PAR4 antagonist (IC50 = 140 nM). Exhibits 70-fold selectivity for PAR4 over PAR1.

Technical Data for ML 354

M. Wt 282.29
Formula C16H14N2O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 89159-60-4
PubChem ID 752812
Smiles CN2C1=CC=C([N+]([O-])=O)C=C1C(C3=CC=CC=C3)=C2CO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ML 354

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 28.23 100

Preparing Stock Solutions for ML 354

The following data is based on the product molecular weight 282.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.54 mL 17.71 mL 35.42 mL
5 mM 0.71 mL 3.54 mL 7.08 mL
10 mM 0.35 mL 1.77 mL 3.54 mL
50 mM 0.07 mL 0.35 mL 0.71 mL

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References for ML 354

References are publications that support the biological activity of the product.

Wen et al (2014) Substituted indoles as selective protease activated receptor 4 (PAR4) antagonists: Discovery and SAR of ML354. Bioorg.Med.Chem.Lett. 24 4708 PMID: 25176330

If you know of a relevant reference for ML 354, please let us know.

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Keywords: ML 354, ML 354 supplier, ML354, SID161004646, VU0099704, selective, protease, activated, receptors, PAR4, antagonists, Protease-Activated, Receptors, 5387, Tocris Bioscience

1 Citation for ML 354

Citations are publications that use Tocris products. Selected citations for ML 354 include:

Sébert et al (2018) Thrombin modifies growth, proliferation and apoptosis of human colon organoids: a protease-activated receptor 1- and protease-activated receptor 4-dependent mechanism. Br J Pharmacol 175 3656 PMID: 29959891

Do you know of a great paper that uses ML 354 from Tocris? Please let us know.

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