ML 228

Discontinued Product

ML 228 (Cat. No. 4565) has been withdrawn from sale for commercial reasons.
Description: HIF pathway activator
Chemical Name: N-([1,1'Biphenyl]-4-ylmethyl)-6-phenyl-3-(2-pyridinyl)-1,2,4-triazin-5-amine
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for ML 228

ML 228 is a HIF pathway activator (EC50 values are 1.23 and 1.4 μM for HRE gene reporter assay and HIF-1α nuclear translocation assay respectively); acts via chelation of iron, independently of PHD. Also exhibits > 80% inhibition of the human A3 receptor, dopamine transporter, μ receptor, hERG and 5-HT2B receptor, and rat sodium channel site 2, at a concentration of 10 μM.

Compound Libraries for ML 228

ML 228 is also offered as part of the Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for ML 228

M. Wt 415.49
Formula C27H21N5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1357171-62-0
PubChem ID 46742353
Smiles C1(C2=NC(NCC4=CC=C(C5=CC=CC=C5)C=C4)=C(C3=CC=CC=C3)N=N2)=NC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for ML 228

References are publications that support the biological activity of the product.

Theriault et al (2012) Discovery of a new molecular probe ML228: an activator of the hypoxia inducible factor (HIF) pathway. Bioorg.Med.Chem.Lett. 22 76 PMID: 22172704

View Related Products by Product Action

View all Hypoxia Inducible Factor (HIF) Activators

Keywords: ML 228, ML 228 supplier, ML228, hypoxia, inducible, factor, HIF, pathway, activators, iron, chelators, HRE, Hypoxia, Inducible, Factors, 4565, Tocris Bioscience

Citations for ML 228

Citations are publications that use Tocris products.

Currently there are no citations for ML 228.

Reviews for ML 228

There are currently no reviews for this product. Be the first to review ML 228 and earn rewards!

Have you used ML 228?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Metabolism Research Product Guide

Cancer Metabolism Research Product Guide

This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:

Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.