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Biological Activity for ML 228
ML 228 is a HIF pathway activator (EC50 values are 1.23 and 1.4 μM for HRE gene reporter assay and HIF-1α nuclear translocation assay respectively); acts via chelation of iron, independently of PHD. Also exhibits > 80% inhibition of the human A3 receptor, dopamine transporter, μ receptor, hERG and 5-HT2B receptor, and rat sodium channel site 2, at a concentration of 10 μM.
Compound Libraries for ML 228
Technical Data for ML 228
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ML 228
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for ML 228
The following data is based on the product molecular weight 415.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.41 mL||12.03 mL||24.07 mL|
|5 mM||0.48 mL||2.41 mL||4.81 mL|
|10 mM||0.24 mL||1.2 mL||2.41 mL|
|50 mM||0.05 mL||0.24 mL||0.48 mL|
References for ML 228
References are publications that support the biological activity of the product.
Theriault et al (2012) Discovery of a new molecular probe ML228: an activator of the hypoxia inducible factor (HIF) pathway. Bioorg.Med.Chem.Lett. 22 76 PMID: 22172704
If you know of a relevant reference for ML 228, please let us know.
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Keywords: ML 228, ML 228 supplier, ML228, hypoxia, inducible, factor, HIF, pathway, activators, iron, chelators, HRE, Hypoxia, Inducible, Factors, 4565, Tocris Bioscience
Citations for ML 228
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Literature in this Area
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