ML 193

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Cat.No. 4860 - ML 193 | C28H25N5O4S | CAS No. 713121-80-3
Description: Potent, selective GPR55 antagonist
Alternative Names: CID 1261822
Chemical Name: N-[4-[[(3,4-Dimethyl-5-isoxazolyl)amino]sulfonyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamide
Purity: ≥98% (HPLC)
Citations (2)

Biological Activity

Selective GPR55 antagonist (IC50 = 221 nM). Exhibits >27-, >145- and >145-fold selectivity for GPR55 over CB1, GPR35 and CB2, respectively. Inhibits ERK signaling in vitro.

Compound Libraries

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Technical Data

M. Wt 527.59
Formula C28H25N5O4S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 713121-80-3
PubChem ID 1261822
Smiles CC2=CC(C)=CC1=C(C(NC4=CC=C(S(=O)(NC5=C(C)C(C)=NO5)=O)C=C4)=O)C=C(C3=CC=CC=N3)N=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 52.76 100

Preparing Stock Solutions

The following data is based on the product molecular weight 527.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.9 mL 9.48 mL 18.95 mL
5 mM 0.38 mL 1.9 mL 3.79 mL
10 mM 0.19 mL 0.95 mL 1.9 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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References are publications that support the biological activity of the product.

Heynen-Genel et al (2010) Screening for selective ligands for GPR55 - antagonists. Probe Reports from the NIH Molecular Libraries Program PMID: 22091481

Kotsikorou et al (2013) Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligands. Biochemistry 52 9456 PMID: 24274581

If you know of a relevant reference for ML 193, please let us know.

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Keywords: ML 193, ML 193 supplier, ML193, CID1261822, GPR55, agonists, potent, selective, agonism, cannabinoids, CID, 1261822, 4860, Tocris Bioscience

2 Citations for ML 193

Citations are publications that use Tocris products. Selected citations for ML 193 include:

Saliba et al (2018) Anti-neuroinflammatory effects of GPR55 antagonists in LPS-activated primary microglial cells. J Neuroinflammation 15 322 PMID: 30453998

Drzazga (2017) Lysophosphatidylcholine elicits intracellular calcium signaling in GPR55-dependent manner. Biochem Biophys Res Commun 489 243 PMID: 28552523

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