Selective GPR55 antagonist (IC50 = 221 nM). Exhibits >27-, >145- and >145-fold selectivity for GPR55 over CB1, GPR35 and CB2, respectively. Inhibits ERK signaling in vitro.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 527.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.9 mL||9.48 mL||18.95 mL|
|5 mM||0.38 mL||1.9 mL||3.79 mL|
|10 mM||0.19 mL||0.95 mL||1.9 mL|
|50 mM||0.04 mL||0.19 mL||0.38 mL|
References are publications that support the biological activity of the product.
Heynen-Genel et al (2010) Screening for selective ligands for GPR55 - antagonists. Probe Reports from the NIH Molecular Libraries Program PMID: 22091481
Kotsikorou et al (2013) Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligands. Biochemistry 52 9456 PMID: 24274581
If you know of a relevant reference for ML 193, please let us know.
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Keywords: ML 193, ML 193 supplier, ML193, CID1261822, GPR55, agonists, potent, selective, agonism, cannabinoids, CID, 1261822, 4860, Tocris Bioscience
1 Citation for ML 193
Citations are publications that use Tocris products. Selected citations for ML 193 include:
Drzazga (2017) Lysophosphatidylcholine elicits intracellular calcium signaling in GPR55-dependent manner. Biochem Biophys Res Commun 489 243 PMID: 28552523
Do you know of a great paper that uses ML 193 from Tocris? Please let us know.
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