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ML 162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor. It induces ferroptosis in vivo. It is selectively lethal to mutant RAS oncogene-expressing cell lines (IC50 = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively).
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 477.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.09 mL||10.47 mL||20.95 mL|
|5 mM||0.42 mL||2.09 mL||4.19 mL|
|10 mM||0.21 mL||1.05 mL||2.09 mL|
|50 mM||0.04 mL||0.21 mL||0.42 mL|
References are publications that support the biological activity of the product.
Luo et al (2022) Intracellular delivery of glutathione peroxidase degrader induces ferroptosis in vivo. Angew.Chem.Int.Ed.Engl. 39 e202206277 PMID: 35924720
Karaj et al (2022) Tunable cysteine-targeting electrophilic heteroaromatic warheads induce ferroptosis. J.Med.Chem. 65 11788 PMID: 35984756
Weïwer et al (2012) Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorg.Med.Chem.Lett. 22 1822 PMID: 22297109
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Keywords: ML 162, ML 162 supplier, ML162, ferroptosis, activator, activates, glutathione, peroxidase, 4, GPX4, covalent, inhibitors, inhibits, Ferroptosis, Other, Reductase, 7821, Tocris Bioscience
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