ML 162

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Description: Inhibits glutathione peroxidase (GPX4); induces ferroptosis
Chemical Name: 2-[(Chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide
Purity: ≥98% (HPLC)

Biological Activity for ML 162

ML 162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor. It induces ferroptosis in vivo. It is selectively lethal to mutant RAS oncogene-expressing cell lines (IC50 = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively).

Technical Data for ML 162

M. Wt 477.41
Formula C23H22Cl2N2O3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1035072-16-2
PubChem ID 3689413
Smiles O=C(NCCC=1C=CC=CC1)C(C=2SC=CC2)N(C(=O)CCl)C3=CC=C(OC)C(Cl)=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ML 162

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 47.74 100
ethanol 9.55 20

Preparing Stock Solutions for ML 162

The following data is based on the product molecular weight 477.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.09 mL 10.47 mL 20.95 mL
5 mM 0.42 mL 2.09 mL 4.19 mL
10 mM 0.21 mL 1.05 mL 2.09 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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References for ML 162

References are publications that support the biological activity of the product.

Luo et al (2022) Intracellular delivery of glutathione peroxidase degrader induces ferroptosis in vivo. Angew.Chem.Int.Ed.Engl. 39 e202206277 PMID: 35924720

Karaj et al (2022) Tunable cysteine-targeting electrophilic heteroaromatic warheads induce ferroptosis. J.Med.Chem. 65 11788 PMID: 35984756

Weïwer et al (2012) Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorg.Med.Chem.Lett. 22 1822 PMID: 22297109

If you know of a relevant reference for ML 162, please let us know.

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Keywords: ML 162, ML 162 supplier, ML162, ferroptosis, activator, activates, glutathione, peroxidase, 4, GPX4, covalent, inhibitors, inhibits, Ferroptosis, Other, Reductase, 7821, Tocris Bioscience

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