ML 161

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Cat.No. 4570 - ML 161 | C17H17BrN2O2 | CAS No. 423735-93-7
Description: Inhibits PAR1-mediated platelet activation
Chemical Name: 2-Bromo-N-[3-[(1-oxobutyl)amino]phenyl]benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50 = 0.26 μM for the inhibition of platelet P-selectin expression on human platelets). Thought to act allosterically. Also inhibits thrombin-induced platelet activation.

Compound Libraries

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Technical Data

M. Wt 361.23
Formula C17H17BrN2O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 423735-93-7
PubChem ID 1048267
InChI Key DFOVLSMXPWPCFH-UHFFFAOYSA-N
Smiles O=C(NC2=CC(NC(CCC)=O)=CC=C2)C1=CC=CC=C1Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.12 100
ethanol 36.12 100

Preparing Stock Solutions

The following data is based on the product molecular weight 361.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.77 mL 13.84 mL 27.68 mL
5 mM 0.55 mL 2.77 mL 5.54 mL
10 mM 0.28 mL 1.38 mL 2.77 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Dockendorff et al (2012) Discovery of 1,3-diaminobenzenes as selective inhibitors of platelet activation at the PAR1 receptor. ACS Med.Chem.Lett. 3 232 PMID: 22408714


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View Related Products by Target

Keywords: ML161 inhibitors inhibits protease-activated proteinase-activated receptors par1 Protease-Activated Receptors

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Literature in this Area

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Pathways for ML 161

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