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ML 161

Cat. No. 4570 Submit a Review Datasheet / COA / SDS
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Description: Inhibits PAR1-mediated platelet activation
Chemical Name: 2-Bromo-N-[3-[(1-oxobutyl)amino]phenyl]benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
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Literature (3)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for ML 161

ML 161 is an inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50 = 0.26 μM for the inhibition of platelet P-selectin expression on human platelets). Thought to act allosterically. Also inhibits thrombin-induced platelet activation.

Technical Data for ML 161

M. Wt 361.23
Formula C17H17BrN2O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 423735-93-7
PubChem ID 1048267
InChI Key DFOVLSMXPWPCFH-UHFFFAOYSA-N
Smiles O=C(NC2=CC(NC(CCC)=O)=CC=C2)C1=CC=CC=C1Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ML 161

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.12 100
ethanol 36.12 100

Preparing Stock Solutions for ML 161

The following data is based on the product molecular weight 361.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.77 mL 13.84 mL 27.68 mL
5 mM 0.55 mL 2.77 mL 5.54 mL
10 mM 0.28 mL 1.38 mL 2.77 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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References for ML 161

References are publications that support the biological activity of the product.

Dockendorff et al (2012) Discovery of 1,3-diaminobenzenes as selective inhibitors of platelet activation at the PAR1 receptor. ACS Med.Chem.Lett. 3 232 PMID: 22408714

If you know of a relevant reference for ML 161, please let us know.

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Citations for ML 161

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Literature in this Area

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