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Submit ReviewML 154
Description: Potent Neuropeptide S receptor antagonist
Chemical Name: 3-(Diphenylphosphinothioyl)-2-methyl-1-[(2E)-3-phenyl-2-propen-1-yl]imidazo[1,2-a]pyridinium bromide
Purity: ≥99% (HPLC)
Biological Activity for ML 154
ML 154 is a potent neuropeptide S receptor (NPSR) antagonist (pA2 = 9.98). Inhibits neuropeptide S-induced ERK phosphorylation over cAMP responses and calcium responses (IC50 values are 9.3, 22.1 and 36.5 nM, respectively). Appears to modulate addictive behavior in vivo. Displays no activity against vasopressin V1B receptors. Brain penetrant.
Technical Data for ML 154
| M. Wt | 545.47 |
| Formula | C29H26N2PS.Br |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 1345964-89-7 |
| PubChem ID | 46930969 |
| InChI Key | CJAQCMBWGUOBIX-ZUQRMPMESA-M |
| Smiles | CC1=C(P(C4=CC=CC=C4)(C5=CC=CC=C5)=S)N3C(C=CC=C3)=[N+]1C/C=C/C2=CC=CC=C2.[Br-] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for ML 154
References for ML 154
References are publications that support the biological activity of the product.
Patnaik et al (2013) Structure-activity relationship of imidazopyridinium analogues as antagonists of neuropeptide s receptor. J Med Chem. 56 9045 PMID: 24171469
Thorsell et al (2013) A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats. J.Neurosci. 33 10132 PMID: 23761908
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Keywords: ML 154, ML 154 supplier, ML154, Potent, selective, Neuropeptide, S, receptors, NPSR, antagonists, ERK, phosphorylation, additive, behaviour, Blood, brain, barrier, permeable, Receptors, 5161, Tocris Bioscience
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