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ML 154

Cat. No. 5161 Submit a Review Datasheet / COA / SDS
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Description: Potent Neuropeptide S receptor antagonist
Chemical Name: 3-(Diphenylphosphinothioyl)-2-methyl-1-[(2E)-3-phenyl-2-propen-1-yl]imidazo[1,2-a]pyridinium bromide
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for ML 154

ML 154 is a potent neuropeptide S receptor (NPSR) antagonist (pA2 = 9.98). Inhibits neuropeptide S-induced ERK phosphorylation over cAMP responses and calcium responses (IC50 values are 9.3, 22.1 and 36.5 nM, respectively). Appears to modulate addictive behavior in vivo. Displays no activity against vasopressin V1B receptors. Brain penetrant.

Technical Data for ML 154

M. Wt 545.47
Formula C29H26N2PS.Br
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1345964-89-7
PubChem ID 46930969
InChI Key CJAQCMBWGUOBIX-ZUQRMPMESA-M
Smiles CC1=C(P(C4=CC=CC=C4)(C5=CC=CC=C5)=S)N3C(C=CC=C3)=[N+]1C/C=C/C2=CC=CC=C2.[Br-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ML 154

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 54.55 100
ethanol 27.27 50

Preparing Stock Solutions for ML 154

The following data is based on the product molecular weight 545.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.83 mL 9.17 mL 18.33 mL
5 mM 0.37 mL 1.83 mL 3.67 mL
10 mM 0.18 mL 0.92 mL 1.83 mL
50 mM 0.04 mL 0.18 mL 0.37 mL

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References for ML 154

References are publications that support the biological activity of the product.

Patnaik et al (2013) Structure-activity relationship of imidazopyridinium analogues as antagonists of neuropeptide s receptor. J Med Chem. 56 9045 PMID: 24171469

Thorsell et al (2013) A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats. J.Neurosci. 33 10132 PMID: 23761908

If you know of a relevant reference for ML 154, please let us know.

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Citations for ML 154

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Literature in this Area

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