MKT 077

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Cat.No. 4621 - MKT 077 | C21H22ClN3OS2 | CAS No. 147366-41-4
Description: Binds mot-2; selectively cytotoxic in cancer cells
Chemical Name: 1-Ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-pyridinium chloride
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (2)

Biological Activity

Occupies mortalin-2 (mot-2), a member of the Hsp70 family, at its p53 binding site and enables p53 translocation to the nucleus. Selectively cytotoxic; causes growth arrest of cancer cells in culture. Also inhibits telomerase activity and cross-links F-actin.

Technical Data

M. Wt 432
Formula C21H22ClN3OS2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 147366-41-4
PubChem ID 3037933
InChI Key VSKYOTRJSLYFHX-UXJRWBAGSA-M
Smiles CN(C1=CC=CC=C1S2)/C2=C4/C(N(CC)/C(S4)=C\C3=CC=CC=[N+]3CC)=O.[Cl-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 21.6 50
DMSO 21.6 50

Preparing Stock Solutions

The following data is based on the product molecular weight 432. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.63 mL 23.15 mL 46.3 mL
2.5 mM 0.93 mL 4.63 mL 9.26 mL
5 mM 0.46 mL 2.31 mL 4.63 mL
25 mM 0.09 mL 0.46 mL 0.93 mL

Molarity Calculator

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References

References are publications that support the biological activity of the product.

Wadhwa et al (2000) Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function. Cancer Res. 60 6818 PMID: 11156371

Wadhwa et al (2002) Rhodacyanine dye MKT-077 inhibits in vitro telomerase activity but has no detectable effects on telomerase activity in vivo. Cancer Res. 62 4434 PMID: 12154051

Tikoo et al (1999) Treatment of Ras-induced cancers by the F-actin cappers tensin and chaetoglobosin K, in combination with the caspase-1 inhibitor N1445. Cancer J.Sci.Am. 5 293 PMID: 10526670

Patury et al (2009) Pharmacological targeting of the Hsp70 chaperone. Curr.Top.Med.Chem. 9 1337 PMID: 19860737


If you know of a relevant reference for MKT 077, please let us know.

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Keywords: MKT 077, MKT 077 supplier, MKT077, heat, shock, proteins, 70, Hsp70, Hsps, inhibitors, inhibits, telomerase, F-actin, cross-linkers, 4621, Tocris Bioscience

1 Citation for MKT 077

Citations are publications that use Tocris products. Selected citations for MKT 077 include:

Chiaw et al (2019) Hsp70 and DNAJA2 limit CFTR levels through degradation. PLoS One 14 e0220984 PMID: 31408507


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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Cancer

Cancer Research Product Guide

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  • Epigenetics in Cancer
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