MKT 077

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Cat.No. 4621 - MKT 077 | C21H22ClN3OS2 | CAS No. 147366-41-4
Description: Binds mot-2; selectively cytotoxic in cancer cells
Chemical Name: 1-Ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-pyridinium chloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Occupies mortalin-2 (mot-2), a member of the Hsp70 family, at its p53 binding site and enables p53 translocation to the nucleus. Selectively cytotoxic; causes growth arrest of cancer cells in culture. Also inhibits telomerase activity and cross-links F-actin.

Compound Libraries

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Technical Data

M. Wt 432
Formula C21H22ClN3OS2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 147366-41-4
PubChem ID 3037933
InChI Key VSKYOTRJSLYFHX-UXJRWBAGSA-M
Smiles CN(C1=CC=CC=C1S2)/C2=C4/C(N(CC)/C(S4)=C\C3=CC=CC=[N+]3CC)=O.[Cl-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 21.6 50
water 21.6 50

Preparing Stock Solutions

The following data is based on the product molecular weight 432. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.31 mL 11.57 mL 23.15 mL
5 mM 0.46 mL 2.31 mL 4.63 mL
10 mM 0.23 mL 1.16 mL 2.31 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Wadhwa et al (2000) Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function. Cancer Res. 60 6818 PMID: 1156371

Wadhwa et al (2002) Rhodacyanine dye MKT-077 inhibits in vitro telomerase activity but has no detectable effects on telomerase activity in vivo. Cancer Res. 62 4434 PMID: 12154051

Tikoo et al (1999) Treatment of Ras-induced cancers by the F-actin cappers tensin and chaetoglobosin K, in combination with the caspase-1 inhibitor N1445. Cancer J.Sci.Am. 5 293 PMID: 10526670

Patury et al (2009) Pharmacological targeting of the Hsp70 chaperone. Curr.Top.Med.Chem. 9 1337 PMID: 19860737


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View Related Products by Target

Keywords: MKT077 heat shock proteins 70 Hsp70 Hsps inhibitors inhibits telomerase inhibitors inhibits F-actin cross-linkers Hsp70

Citations for MKT 077

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease

Pathways for MKT 077

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