MK 571

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Description: Potent CysLT1 (LTD4) inverse agonist. Also MRP1 inhibitor
Alternative Names: L-660711
Chemical Name: 3-[[[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]propanoic acid
Citations (5)

Biological Activity for MK 571

MK 571 is a potent CysLT1 (LTD4) leukotriene receptor inverse agonist (EC50 = 1.3 nM). Antagonizes LTD4-induced contractions of guinea pig trachea and ileum (pA2 values are 9.4 and 10.5 respectively). Also inhibitor of multidrug resistance protein-1 (MRP1) mediated transport; in vitro augments the effects of cytotoxic agents on malignant cells.

Technical Data for MK 571

M. Wt 515.09
Formula C26H27ClN2O3S2
Storage Store at -20°C
CAS Number 115104-28-4
PubChem ID 5281888
Smiles ClC1=CC=C(C=CC(/C=C/C3=CC(C(SCCC(O)=O)SCCC(N(C)C)=O)=CC=C3)=N2)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MK 571

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 51.51 100

Preparing Stock Solutions for MK 571

The following data is based on the product molecular weight 515.09. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.94 mL 9.71 mL 19.41 mL
5 mM 0.39 mL 1.94 mL 3.88 mL
10 mM 0.19 mL 0.97 mL 1.94 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

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Product Datasheets for MK 571

Certificate of Analysis / Product Datasheet
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References for MK 571

References are publications that support the biological activity of the product.

Vellenga et al (1999) Interleukin-6 production by activated human monocytic cells is enhanced by MK-571, a specific inhibitor of the multi-drug resistance protein-1. Br.J.Pharmacol. 127 441 PMID: 10385244

Dupre et al (2004) Inverse agonist activity of selected ligands of the cysteinyl-leukotriene receptor 1. J.Pharmacol.Exp.Ther. 309 102 PMID: 14718577

Blain and Sirois (2000) Involvement of LTD4 in allergic pulmonary inflammation in mice: modulation by cysLT1 antagonist MK-571. Prost.Leuko.Essent.Fatty Acids 62 361

If you know of a relevant reference for MK 571, please let us know.

View Related Products by Product Action

View all Leukotriene and Related Receptor Inverse Agonists

Keywords: MK 571, MK 571 supplier, Potent, CysLT1, LTD4, inverse, agonists, MRP, inhibitors, inhibits, Receptors, leukotrienes, eicosanoids, MDR, Resistance, Protein, Multidrug, Transporters, MK571, L660711, L-660711, Leukotriene, and, Related, 2338, Tocris Bioscience

5 Citations for MK 571

Citations are publications that use Tocris products. Selected citations for MK 571 include:

Schnúr et al (2019) Phosphorylation-dependent modulation of CFTR macromolecular signalling complex activity by cigarette smoke condensate in airway epithelia. Sci Rep 9 12706 PMID: 31481727

Wright et al (2019) Pranlukast is a novel small molecule activator of the two-pore domain potassium channel TREK2. Biochem Biophys Res Commun 520 35 PMID: 31564414

Stott et al (2015) A primary fish gill cell culture model to assess pharmaceutical uptake and efflux: evidence for passive and facilitated transport. Antimicrob Agents Chemother 159 127 PMID: 25544062

Hoque et al (2015) Raltegravir permeability across blood-tissue barriers and the potential role of drug efflux transporters. Biochem Pharmacol 59 2572 PMID: 25691630

Do you know of a great paper that uses MK 571 from Tocris? Please let us know.

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