MK 217

Pricing Availability Delivery Time Qty
Cat.No. 4014 - MK 217 | C4H12NNaO7P2 | CAS No. 129318-43-0
Description: Inhibitor of farnesyl diphosphate synthase (FPPS) and osteoclast-mediated bone resorption
Alternative Names: Alendronate sodium
Chemical Name: P,P'-(4-Amino-1-hydroxybutylidene)bis-phosphonic acid monosodium salt

Biological Activity

Osteoclast-mediated bone resorption inhibitor. Binds and blocks farnesyl diphosphate synthase (FPPS) in the HMG-CoA pathway (IC50 = 460 nM for recombinant human FPPS); causes macrophage apoptosis. Inhibits prenylation and sterol biosynthesis in purified osteoclasts.

Technical Data

M. Wt 271.08
Formula C4H12NNaO7P2
Storage Desiccate at -20°C
CAS Number 129318-43-0
PubChem ID 62958
Smiles [Na+].NCCCC(O)(P(O)(O)=O)P(O)([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 13.55 50

Preparing Stock Solutions

The following data is based on the product molecular weight 271.08. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.69 mL 18.44 mL 36.89 mL
5 mM 0.74 mL 3.69 mL 7.38 mL
10 mM 0.37 mL 1.84 mL 3.69 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Bergstrom et al (2000) Alendronate is a specific, nanomolar inhibitor of fanesyl diphosphate synthase. Arch.Biochem.Biophys. 373 231 PMID: 10620343

Fournier et al (2008) Lowering bone mineral affinity of bisphosphonates as a therapeutic strategy to optimize skeletal tumor growth inhibition in vitro. Cancer Res. 68 8945 PMID: 18974139

Fisher et al (1999) Alendronate mechanism of action; geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro. Proc.Natl.Acad.Sci. 96 133 PMID:

If you know of a relevant reference for MK 217, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Other Synthase/Synthetase Inhibitors

Keywords: MK 217, supplier, MK217, osteoclasts, mediated, bone, resorption, osteoporosis, inhibits, farnesyl, diphosphate, synthase, inhibitors, Alendronate, sodium, Other, Synthases/Synthetases, Other, Synthases/Synthetases, Tocris Bioscience

Citations for MK 217

Citations are publications that use Tocris products.

Currently there are no citations for MK 217. Do you know of a great paper that uses MK 217 from Tocris? If so please let us know.

Commented out for usability testing


TODO: Add Reviews

Literature in this Area


Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for MK 217


TODO: Add Protocols