MK 217

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Cat.No. 4014 - MK 217 | C4H12NNaO7P2 | CAS No. 129318-43-0
Description: Inhibitor of farnesyl diphosphate synthase (FPPS) and osteoclast-mediated bone resorption
Alternative Names: Alendronate sodium
Chemical Name: P,P'-(4-Amino-1-hydroxybutylidene)bis-phosphonic acid monosodium salt
Datasheet
Citations
Literature

Biological Activity

Osteoclast-mediated bone resorption inhibitor. Binds and blocks farnesyl diphosphate synthase (FPPS) in the HMG-CoA pathway (IC50 = 460 nM for recombinant human FPPS); causes macrophage apoptosis. Inhibits prenylation and sterol biosynthesis in purified osteoclasts.

Technical Data

M. Wt 271.08
Formula C4H12NNaO7P2
Storage Desiccate at -20°C
CAS Number 129318-43-0
PubChem ID 62958
InChI Key CAKRAHQRJGUPIG-UHFFFAOYSA-M
Smiles [Na+].NCCCC(O)(P(O)(O)=O)P(O)([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 13.55 50

Preparing Stock Solutions

The following data is based on the product molecular weight 271.08. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.69 mL 18.44 mL 36.89 mL
5 mM 0.74 mL 3.69 mL 7.38 mL
10 mM 0.37 mL 1.84 mL 3.69 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Bergstrom et al (2000) Alendronate is a specific, nanomolar inhibitor of fanesyl diphosphate synthase. Arch.Biochem.Biophys. 373 231 PMID: 10620343

Fournier et al (2008) Lowering bone mineral affinity of bisphosphonates as a therapeutic strategy to optimize skeletal tumor growth inhibition in vitro. Cancer Res. 68 8945 PMID: 18974139

Fisher et al (1999) Alendronate mechanism of action; geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro. Proc.Natl.Acad.Sci. 96 133 PMID:


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