Milameline hydrochloride

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Cat.No. 2604 - Milameline hydrochloride | C8H14N2O.HCl | CAS No. 139886-04-7
Description: Muscarinic receptor agonist
Chemical Name: (E)-1,2,5,6-Tetrahydro-1-methyl-3-pyridinecarboxaldehyde O-methyloxime hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Muscarinic receptor agonist that displays roughly equal affinity at all receptor subtypes (Ki values are 2.3, 2.4, 3.6, 3.8 and 4.3 μM for hM1, hM2, hM3, hM4 and hM5 receptors respectively). Cognitive enhancer; reverses spatial memory deficits in rats.

Technical Data

M. Wt 190.67
Formula C8H14N2O.HCl
Storage Desiccate at -20°C
Purity ≥99% (HPLC)
CAS Number 139886-04-7
PubChem ID 9571001
InChI Key WEBMRZODPLSRKR-MLBSPLJJSA-N
Smiles CN1CC(/C=N/OC)=CCC1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 19.07 100

Preparing Stock Solutions

The following data is based on the product molecular weight 190.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.24 mL 26.22 mL 52.45 mL
5 mM 1.05 mL 5.24 mL 10.49 mL
10 mM 0.52 mL 2.62 mL 5.24 mL
50 mM 0.1 mL 0.52 mL 1.05 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Sedman et al (1995) Preclinical and phase I clinical characterization of CI-979/RU35926, a novel muscarinic agonist for the treatment of Alzheimer's disease. Life Sci. 56 877 PMID: 10188788

Wood et al (1999) Functional comparison of muscarinic partial agonists at muscarinic receptor subtypes hM1, hM2, hM3, hM4 and hM5 using microphysiometry. Br.J.Pharmacol. 126 1620 PMID: 10323594

Schwarz et al (1999) Milameline (CI-979/RU35926): a muscarinic receptor agonist with cognition-activating properties: biochemical and in vivo characterization. J.Pharmacol.Exp.Ther. 291 812 PMID: 10525104


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Keywords: Milameline hydrochloride, supplier, Muscarinic, receptors, agonists, Acetylcholine, ACh, Non-selective, Muscarinics, Tocris Bioscience

Citations for Milameline hydrochloride

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